Stressor-induced alterations in serotonergic ...
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Citation
| Title | Stressor-induced alterations in serotonergic activity in an animal model of depression |
| Author(s) | T. Connor, C. Song, B. Leonard, H. Anisman, Z. Merali |
| Journal | Neuroreport: For Rapid Communication of Neuroscience Research |
| Date | 1999 |
| Volume | 10 |
| Issue | 3 |
| Start page | 523 |
| End page | 528 |
| Abstract | Examined the effect of 2 neurogenic stressors (air puff and restraint) and a metabolic stressor (lipopolysaccharide; 100 ?g/kg) on accumbal serotonergic neurotransmission in the olfactory bulbectomized (OB) rat model of depression. Male Sprague-Dawley rats were used in 2 studies. Both puff and restraint stress caused greater increases in accumbal 5-hydroxyindoleacetic acid (5-HIAA) in OB vs sham-operated rats. In contrast, bulbectomy resulted in a blunted serotonergic response to a challenge with the metabolic stressor. In addition, OB rats displayed significantly basal levels of 5-HIAA than sham-operated Ss, a finding consistent with previous reports of the OB rat being a model of hyposerotonergic depression. The relevance of these findings to stressor-provoked depressive-like behaviors in the OB rat is discussed. |
| ISSN | 0959-4965,1473-558X |
Using APA 6th Edition citation style.
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