Glutathione transferase mu deficiency is not a ...
Description
Citation
| Title | Glutathione transferase mu deficiency is not a marker for predisposition to sulphonamide toxicity |
| Author(s) | R. Riley, A. Cribb, S. Spielberg |
| Journal | Biochemical pharmacology |
| Date | 1991 |
| Volume | 42 |
| Issue | 3 |
| Start page | 696 |
| End page | 698 |
| Abstract | Glutathione transferase mu activity, a marker for susceptibility to lung cancer and chemically induced cytogenetic damage, is not a predictive index for the predisposition to sulphonamide hypersensitivity reactions. However, considering the functional diversity and broad, overlapping substrate specificity of GSH-dependent enzymes, it is conceivable that an as yet unidentified deficiency in another GST isozyme or GSH-related enzyme may be a marker for sulphonamide toxicity. In addition, heterogeneity in cellular repair mechanisms and the diversity of the human immune response [22] may also contribute to the manifestation of the toxic effects of sulphonamides. Experiments are currently in progress to determine which of this myriad of variables is predominantly responsible for inter-individual susceptibility to the idiosyncratic reactions produced by these antibacterial agents. |
| ISSN | 0006-2952 |
Using APA 6th Edition citation style.
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]
Times viewed: 70
