Prenatal exposure to antiadrenergic antihypertensive drugs
effects on neurobehavioral development and the behavioral consequences of enriched rearing
Ryan, Catherine L.Pappas, Bruce A.
Neurotoxicology and Teratology
Administered one of the beta blockers propranolol (5 or 20 mg/kg) or atenolol (5 or 20 mg/kg) or the alpha-2 agonist clonidine (20 or 100 ?g/kg) in the drinking water to pregnant rats over Gestation Days 1-21. Prenatal exposure to the drugs did not alter the beneficial effects of enriched rearing on maze solving. However, clonidine-exposed (100 ?g/kg) female rats that were raised in enrichment showed a significantly increased mortality rate.