Anaphylactoid reactions to Mellavax [Salmonella dublin vaccine] in calves

Burka, John F.
Scarnell, J.

Veterinary Record

Journal Article

1978

102

22

483

484

Biomedical Sciences

Mellavax (avirulent S. dublin vaccine) appears to cause an anaphylactoid reaction in a ratio of 1:28 000 doses sold. A clinical picture of respiratory embarrassment and pulmonary oedema occurs. Histamine, 5-HT and dopamine are implicated mediators released during the reaction but to a minor extent compared with prostaglandins, which appear to play a major role in calves. Sodium meclofenamate, aspirin and indomethacin protect calves during acute systemic anaphylaxis and should be used in addition Show moreMellavax (avirulent S. dublin vaccine) appears to cause an anaphylactoid reaction in a ratio of 1:28 000 doses sold. A clinical picture of respiratory embarrassment and pulmonary oedema occurs. Histamine, 5-HT and dopamine are implicated mediators released during the reaction but to a minor extent compared with prostaglandins, which appear to play a major role in calves. Sodium meclofenamate, aspirin and indomethacin protect calves during acute systemic anaphylaxis and should be used in addition to adrenalin.. Show less

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