Inhibition of phagosome-lysosome fusion in macrophages by soluble extracts of virulent Brucella abortus
Frenchick, P. J.Markham, R. J. FrederickCochrane, A. H.
American Journal of Veterinary Research
Pathology and Microbiology
Water extracts of virulent Brucella abortus were able to inhibit phagosome-lysosome fusion in unelicited murine peritoneal macrophages following ingestion of yeast. Extracts from an avirulent strain were unable to produce a similar effect. Lipopolysaccharide from B abortus did not appear to be involved with the ability of the extracts to inhibit fusion.