The in vitro immunosuppressive effects of moclobemide in healthy volunteers

Lin, Aihua
Song, Cai
Kenis, G?
Bosmans, Eugene
De Jongh, Raf
Scharp?, Simon
Maes, Michael

Journal of Affective Disorders

Journal Article

2000

58

1

69

74

Biomedical Sciences

Examined, in 9 normal volunteers (mean age 33.1 yrs), the in vitro effects of moclobemide on the production of interleukin-6 (IL-6), IL-8, tumor necrosis factor-? (TNF?), interferon-? (IFN?), IL-10 and the IL-1 receptor antagonist (IL-1RA) by diluted whole blood stimulated or not with lipopolysaccharide (LPS) + phytohemagglutinin. Moclobemide 10-super(-3 ) and 10-super(-5 )significantly suppressed the unstimulated production of TNF? and IL-8, and significantly enhanced the stimulated-production Show moreExamined, in 9 normal volunteers (mean age 33.1 yrs), the in vitro effects of moclobemide on the production of interleukin-6 (IL-6), IL-8, tumor necrosis factor-? (TNF?), interferon-? (IFN?), IL-10 and the IL-1 receptor antagonist (IL-1RA) by diluted whole blood stimulated or not with lipopolysaccharide (LPS) + phytohemagglutinin. Moclobemide 10-super(-3 ) and 10-super(-5 )significantly suppressed the unstimulated production of TNF? and IL-8, and significantly enhanced the stimulated-production of IL-10. The production of IL-6, IL-1RA and IFN? was not significantly affected either in the unstimulated or stimulated conditions. Mocloberaide has negative immunoregulatory capacities through inhibition of the production of proinflammatory cytokines, i.e. TNF? and IL-8, and through enhancement of the production of IL-10, an anti-inflammatory cytokine. Show less

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