In vitro immunoregulatory effects of lithium in healthy volunteers
Maes, MichaelSong, CaiLin, Ai-huaPioli, RosariaKenis, GunterKubera, MartaBosmans, Eugene
Examined the in vitro effects of lithium carbonate on the unstimulated and lipolysaccharide (LPS)?+?phytohemagglutinin (PHA)-induced production of proinflammatory cytokines, such as interleukin-6 (IL-6), IL-8, tumor necrosis factor-? (TNF?) and interferon-? (IFN?), and negative immunoregulatory cytokines or proteins, such as IL-10 and the IL-1 receptor antagonist (IL-1RA).