Changes in behaviour, neurotransmitters and neutrophil function in olfactory bulbectomized rats
effects of chronic desipramine treatment
Song, CaiLeonard, B. E.
Human Psychopharmacology: Clinical and Experimental
The olfactory bulbectomized (OB) rat has been developed as an animal model of depression. In the novel "open field" environment, male OB rats showed a hyperactivity which was attenuated by chronic treatment with desipramine (7.5 mg/ kg) for 20 days. Neutrophil phagocytosis was suppressed by the lesion, which was reversed by desipramine administration. Results from serum crossover studies and enzyme assay showed that some factor in the serum of OB rats may suppress neutrophil phagocytosis.