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A collection of graduate theses by UPEI masters and doctoral students.

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The purpose of this study is to describe the geographic distribution of Aboriginal people who live in remote, isolated Aboriginal communities in Canada in terms of how geographic settings and features, particularly those that are characteristic of island dwellers, are related to and can impact aspec...
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This thesis addresses issues of islandness and island identity in the fiction of Cape Breton's Alistair MacLeod and Newfoundland's Wayne Johnston. Through careful readings of their fiction, with supplementary evidence culled from biographical and secondary sources, the thesis shows that their work i...
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Marine invertebrates, including octocorals, are a prolific source of marine natural products (MNPs) and are also known to host diverse microbial communities. It is well-established that marine microbes are producers of bioactive secondary metabolites. Accordingly, it is hypothesized that bioactive m...
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Background: The youth population of Prince Edward Island (PEI) is one of the least active in all of Canada (Colley et al., 2012). The social factors that influence youth physical activity (PA) behaviours are not well understood. There is a body of evidence which suggests there is a relationship betw...
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An in vitro comparison of the osteogenic potential of equine stem cell populations and subpopulations from multiple tissue sources was made to identify the ideal equine donor tissue as a source of MSCs to promote bone healing. Equine muscle tissue– and periosteal tissue–derived cells where chara...
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Potato farming and lobster fishing are two important industries on Prince Edward Island. However for both industries to be sustainable, they must be managed responsibly. Recently, agricultural runoff has been suspected to have caused numerous fish kills in rivers throughout the island. Although a pe...
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The American lobster (Homarus americanus) is harvested along the eastern seaboard of North America and forms the economic backbone of many small fishing communities in Atlantic Canada and the northeastern United States. The industry sets minimum size (carapace length) for harvesting American lobster...
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The United Nations Convention on the Law of the Sea (UNCLOS) contained a specific section for “Archipelagic States” (Part IV) which are given many rights under the archipelagic regime including, if desired, to designate archipelagic sea lanes (ASLs) through their archipelagic waters. While desig...
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The objectives of this thesis were: 1) to determine which factors and biological samples were associated with the estimated amount of total arsenic (As) consumed from water and food; 2) to determine which factors were associated with the concentration of total and speciated As ([As]) in urine; 3) to...
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Obesity has become an increasingly common health condition over the last several decades. It has been estimated that this largely preventable disease affects over one billion people worldwide and that its prevalence will have doubled by the year 2030. Currently, obesity is the leading cause of preve...
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The field of fungal taxonomy has been enduring in recent years due to the progress and application of molecular tools used in concert with morphological analysis. The fungal kingdom is extremely diverse and estimated to include 1.5 million species. Only 11% of these fungi are currently described in ...
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Schizophrenia is a devastating neurological disorder that affects approximately 1% of the population and is characterized by positive, negative, and/or cognitive symptoms. Positive symptoms are associated with increased glutamate (Glu) and/or dopamine (DA) signaling in the nucleus accumbens (NAcc) w...
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Alcyonacean octocorals (Order Alcyonacea, amended from Order, Gorgoniidae) are both dominant on Caribbean reefs and prolific sources of bioactive natural products. Although extensive literature has been published with respect to stony coral-associated bacteria, very little is known regarding bacteri...
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This thesis brings together the study of islands, anthropology, and postcolonialism; it discusses (1) how global assemblages, such as colonial interactions and neoliberal economies influence individual well-being and local health care ontologies as practice on islands, and (2) the space and place of...
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The emergence of Caribbean small island states (SIS) through the 'demonstration effect‘ has resulted in even some of the smallest Caribbean islands achieving sovereignty. Past conventional security threats, such as the 1983 coup and intervention in Grenada, have resulted in the US Commonwealth Car...
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Lepeophtheirus salmonis is a copepod parasite of salmonid fish, commonly referred to as sea lice, and is particularly pathogenic to Atlantic salmon (Salmo salar). Although endemic on wild salmon, L. salmonis infection intensity rarely reaches clinical disease levels in wild fish. The stationary natu...
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Mast cells are crucial effector cells in host defense and immunoregulation. They are equipped with an impressive array of receptor systems which allows them to rapidly respond to pathogen-associated signals. G protein-coupled receptors (GPCRs) mediate mast cell activation and mediator release in res...
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Sturgeon are harvested worldwide for their meat and eggs, sold as caviar and are among the most economically important fish species worldwide. A generally low physiological response to external stimuli/stressors has been documented in these phylogenetically primitive species. Considering how little ...
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In controlled release, each patient’s body displays different pharmacokinetics for the degradation of the drug delivery system affecting the release of the bioactive compound. The proposed research aims to develop polymeric systems based on a host/guest core capable of indicating controlled releas...
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Syndromic surveillance is a tool for continuous, automated extraction of surveillance information from health data sources. The research documented in this dissertation aimed at exploring informatics and data mining tools in order to develop and implement techniques to harvest additional surveillanc...
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The American lobster (Homarus americanus) is the most economically significant commercial fishery species in Canada. The Canadian lobster fishery provides tens of thousands of jobs, and is the economic driver of hundreds of rural communities in Atlantic Canada and Quebec. The adult lobster is suscep...
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Neuropsychiatric disorders affect a significant number of people across the globe and are a serious economic and social burden. As a class of diseases they are often poorly understood, difficult to treat, and can lead to a significant decline in normal function and quality of life. Recent evidence s...
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Natural products have long been recognized for their medicinal value in traditional medicine and remain an important component of modern drug discovery. Known for their immense structural diversity, natural products are secondary metabolites that often exhibit unique pharmacological properties. In t...
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The Pacific Island Countries including the Fiji Islands are heavily dependent on imported petroleum fuels for their energy needs. This is a major cause of environmental vulnerability as well as economic vulnerability due to high and volatile crude oil prices. A combination of Demand Side Management ...
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BACKGROUND Myocardial fibrosis is a hallmark of hypertrophic cardiomyopathy (HCM). Human patients with HCM have high serum concentrations of biomarkers of collagen synthesis, indicating a profibrotic state. This abnormality exists in sarcomere mutation carriers both with and without overt left ventr...