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A novel degradative route to pregnanes has been elucidated in the marine sponge Araphimedon compressa. 22-Dehydrosterols, common in the diet of sponges, are the precursors to pregnanes and apparently are degraded by a mechanism analogous to the dealkylation of phytosterols to cholesterol.
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Cyclobutenbriarein A (2), a novel class of C20-rearranged diterpene briarane possessing an unprecedented tricyclo[8.4.0.0(3,6)]tetradec-4-ene ring system was isolated, along with five new briarane diterpenoids (1 and 3-6), from the organic extracts of the Bahamian gorgonian Briareum asbestinum. The ...
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The pseudopterosins are a family of diterpene glycosides isolated from the gorgonian coral Pseudopterogorgia elisabethae. These metabolites exhibit potent anti-inflammatory activity, and this review describes our efforts to elucidate their biosynthetic origin. A radioactivity-guided isolation was us...
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The pseudopterosins are diterpene glycosides isolated from the marine gorgonian, Pseudopterogorgia elisabethae, which exhibit anti-inflammatory and analgesic activity greater than the industry standard, indomethacin. Previously, we isolated the pseudopterosin diterpene cyclase product, elisabethatri...
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OBJECTIVE. To determine the effects of continuous passive motion (CPM) and immobilization on synovitis and cartilage degradation in an experimental model of chronic inflammatory, antigen-induced arthritis. METHODS. After bilateral arthritis induction of knee joints in 22 NZW rabbits, one knee was im...
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The triterpene precursor of saponins in sea cucumbers has been identified as parkeol [lanost-9(11)-en-3 beta-ol] [1]. Dissection of the sea cucumbers Holothuria floridea and Actinopyga agassize after incubations with radiolabeled parkeol demonstrated that saponin biosynthesis occurs exclusively in t...
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Two new sterols, epipolasterol and 22(23)-dihydroepipolasterol, have been isolated from the marine sponge Epipolasis sp. These are unusual metabolites as they both contain a t-butyl group in the sterol side chain. In addition, the presence of two degrees of unsaturation in the side chain of epipolas...
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Isochrysis galbana, one of the most widely used marine microalgae in the rearing of finfish and shellfish larvae, is mass cultured frequently in outdoor tanks. Under prolonged and repeated culture, severe contamination occurs. Axenic isolation of I. galbana from such cultures was best achieved by us...
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A biosynthetic study has been performed to elucidate the precise mechanisms of sterol side chain dealkylation in marine sponges. This process resembles that of insects by involving the oxidation of common dietary sterols with unsaturation at C-24(28) (24-methylenecholesterol (8), fucosterol (3), and...
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The potential use of bFGF immortalized cells as hosts for delivering foreign genes into nervous tissue led us to examine the effect of maintaining, E-18 hippocampal neurons for extended periods in bFGF culture prior to transfer into a standard, serum-containing, medium. We found: (1) many, if not mo...
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The possibility that neurons cultured in basic fibroblast growth factor (bFGF) are heterogeneous raises concerns about their subsequent use in gene transfection and transplantation studies. We have examined the fate of embryonic hippocampal neurons in bFGF culture, and now conclude that these cells ...
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