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1. The transient outward potassium current (Ito) is reduced in canine epicardial myocytes during the acute stage of infection with Trypanosoma cruzi (Chagas' disease). Sympathetic nerve terminals are also destroyed during the acute stage of this disease. To test whether the reduction of Ito is relat...
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Sudden cardiac death, secondary to ventricular fibrillation (VF), remains the leading cause of death in the USA. Recent experimental and theoretical studies suggest that VF could be caused by spiral wave re-entry. The initiation and subsequent break-up of spiral waves has been linked to electrical a...
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We have shown previously that verapamil reduces the slope of the action potential duration (APD) restitution relation, suppresses APD alternans and converts ventricular fibrillation (VF) into a periodic rhythm. To determine whether these effects result primarily from reduction of the APD restitution...
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Introduction: Methods and Results: Conclusion: A colony of inbred German shepherd dogs with inherited ventricular arrhythmias has been established.The inward rectifier (IK1), the slow delayed rectifier (IKs), and the transient outward current (I(to)) were recorded from epicardial myocytes, and Ito w...
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The restitution kinetics of action potential duration (APD) were investigated in paced canine Purkinje fibers (P; n = 9) and endocardial muscle (M; n = 9), in isolated, perfused canine left ventricles during ventricular fibrillation (VF; n = 4), and in endocardial muscle paced at VF cycle lengths (s...
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Suppression of electrical alternans may be antiarrhythmic. Our previous computer simulations have suggested that increasing the rapid component of the delayed rectifier K(+) current (I(Kr)) suppresses alternans. To test this hypothesis, I(Kr) in isolated canine ventricular myocytes was increased by ...
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The contribution of cumulative changes in action potential duration (memory) to complex cellular electrophysiological behavior was investigated in canine cardiac Purkinje fibers. Complex behavior induced during constant pacing was caused by reciprocal interactions between the time to full repolariza...
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The article discusses how the techniques of nonlinear dynamics can applied to the study and prevention of cardiac arrhythmias or heart rhythm disorders. The authors discuss how cardiac alternans offer a new therapeutic approach to treating heart rhythm disorders. Alternans are period doubling oscill...
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From a group of 46 young racing Standardbreds presented for problems of decreased athletic performance, 8 with complete physiological data were found to have blood in the trachea (POS) within 1 h after a maximum exercise test on a high speed treadmill. This group was compared to those horses which h...
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A novel degradative route to pregnanes has been elucidated in the marine sponge Araphimedon compressa. 22-Dehydrosterols, common in the diet of sponges, are the precursors to pregnanes and apparently are degraded by a mechanism analogous to the dealkylation of phytosterols to cholesterol.
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Cyclobutenbriarein A (2), a novel class of C20-rearranged diterpene briarane possessing an unprecedented tricyclo[8.4.0.0(3,6)]tetradec-4-ene ring system was isolated, along with five new briarane diterpenoids (1 and 3-6), from the organic extracts of the Bahamian gorgonian Briareum asbestinum. The ...
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The pseudopterosins are a family of diterpene glycosides isolated from the gorgonian coral Pseudopterogorgia elisabethae. These metabolites exhibit potent anti-inflammatory activity, and this review describes our efforts to elucidate their biosynthetic origin. A radioactivity-guided isolation was us...
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The pseudopterosins are diterpene glycosides isolated from the marine gorgonian, Pseudopterogorgia elisabethae, which exhibit anti-inflammatory and analgesic activity greater than the industry standard, indomethacin. Previously, we isolated the pseudopterosin diterpene cyclase product, elisabethatri...
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OBJECTIVE. To determine the effects of continuous passive motion (CPM) and immobilization on synovitis and cartilage degradation in an experimental model of chronic inflammatory, antigen-induced arthritis. METHODS. After bilateral arthritis induction of knee joints in 22 NZW rabbits, one knee was im...
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The triterpene precursor of saponins in sea cucumbers has been identified as parkeol [lanost-9(11)-en-3 beta-ol] [1]. Dissection of the sea cucumbers Holothuria floridea and Actinopyga agassize after incubations with radiolabeled parkeol demonstrated that saponin biosynthesis occurs exclusively in t...