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There is considerable pressure for Animal Care and Ethics Councils to recommend using analgesics in experiments that involve fish. Although we do have some data regarding this issue, I argue that we do not know enough to recommend any being used. For example, the doses of morphine used in fish exper...
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The safety of shellfish found and consumed in Nigeria is doubtful because no investigations have been carried out on their toxicity. The occurrence and toxicity of toxins in the commonly consumed Nigerian shellfish from Lagos, Warri, Oron, and Port Harcourt (PH) were investigated. Albino Wistar mice...
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(+)-Bufuralol 1'-hydroxylation, a commonly used marker of hepatic CYP2D6 activity, was investigated in human and rhesus monkey intestinal microsomes and compared with that in hepatic microsomes. The cumene hydroperoxide (CuOOH)-mediated metabolism of (+)-bufuralol suggested that at least two enzymes...
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Chemical studies on the non polar fraction of the methanolic extract of Pseudopterogorgia elisabethae Bayer collected from the Florida Keys has yielded 12-acetoxypseudopterolide (1), a new diterpene of the pseudopterane series. The structure was established through spectroscopic analysis. Compound (...
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In the present investigation, in vivo microdialysis was used to measure the concentration of estrogen in the parabrachial nucleus (PBN) and plasma of male and ovariectomized female Sprague-Dawley rats supplemented with either estrogen (OVX-E(2)) or saline (OVX-S) following visceral afferent activati...
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The steroid hormone 17 beta-estradiol and its respective receptors have been found in several cardiovascular nuclei in the central nervous system including the parabrachial nucleus. In a previous study, we provided evidence that 17 beta-estradiol attenuated an outward potassium conductance in parabr...
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The steroid hormone 17beta-estradiol and its respective receptors have been found in several cardiovascular nuclei in the central nervous system including the parabrachial nucleus. In a previous study, we provided evidence that 17beta-estradiol attenuated an outward potassium conductance in parabrac...
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Evidence is increasingly accumulating in support of a role for the steroid hormone 17beta-estradiol to modify neuronal functions in the mammalian CNS, especially in autonomic centers. In addition to its well known slowly developing and long lasting actions (genomic), estrogen can also rapidly modula...
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Evidence is increasingly accumulating in support of a role for the steroid hormone 17 beta-estradiol to modify neuronal functions in the mammalian CNS, especially in autonomic centers. In addition to its well known slowly developing and long lasting actions (genomic), estrogen can also rapidly modul...
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The following experiments examine the role of estrogen as a central modulator of autonomic tone and baroreflex sensitivity in the female rat. Female Sprague-Dawley rats were ovariectomized and then supplemented daily for 7 days with a fixed dose of estrogen (5 microg/kg; sc) to produce a stable leve...
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Most athletes stretch as part of their training regimen and it is commonly believed that this practice prevents muscle injury. We tested this belief using an animal model, in situ mouse extensor digitorum longus (EDL) muscle. One lower hindlimb was slowly stretched for 1 min on alternate days for 12...
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The recent detection of the invasive colonial tunicate Diplosoma listerianum in Havre- Aubert, Magdalen Islands (Quebec, Canada) in 2008, prompted the development of a molecular assay as a method to detect and monitor for the potential invasion of this species in Prince Edward Island. The aim of thi...
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The characteristics of 227 biting dogs, their homes, and their victims were gathered in a detailed telephone survey of general veterinary clientele in the Canadian provinces of New Brunswick, Nova Scotia, and Prince Edward Island. All of the dogs had bitten either someone living in the same househol...
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Using random allocation, 92 clinically healthy dogs were restrained chemically using fentany/droperidol, and 71 using oxymorphone/acepromazine, for radiography. Questionnaires completed by the radiology department revealed no significant differences between the drug combinations either in effectiven...
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The histology and mucus histochemistry of the pleuronectid post-gastric alimentary canal was examined using light and electron microscopy. Distinct differences in goblet cell mucus histochemistry were observed between species, with the two closest taxonomic species, the winter flounder and the yello...
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The morphology and the histochemistry of the mucus of the pleuronectid stomach were examined using light and electron microscopy. The stomach of the winter flounder (Pleuronectes americanus) and the yellowtail flounder (Pleuronectes ferruginea) possessed a glandular or cardiac region and an aglandul...
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Glutamic acid (GA) and kainic acid (KA) are structurally related to domoic acid (DOM), a neurotoxic amino acid that caused human food poisoning in 1987, following consumption of toxic mussels (Mytilus edulis ) from Prince Edward Island, Canada. To study the difference in response of mussels to a phy...
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Ovalbumin (OA) and the calcium ionophore A23187 induced a dose-dependent contraction of guinea pig tracheal strips. The OA-induced contraction (of sensitized trachea) consisted of an initial peak concentration, maximal between 5 and 10 min, followed by a very gradual decline from the peak. On the ot...
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Nine healthy mixed-breed dogs weighing between 15 and 28 kg were anaesthetized with 33% oxygen, 67% nitrous oxide and halothane. Oxygen flow rates of 10, 20 and 30 ml/kg per minute were administered with appropriate nitrous oxide flow rates for three consecutive 45-minute periods. Inspired oxygen co...
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Cartilage structures of the sea lamprey, Petromyzon marimus, have previously been reported to stain by the Verhoeff method for elastin and to have a morphology similar to that of elastic cartilage of higher vertebrates. Earlier we showed that lamprin, the major matrix protein of lamprey annular cart...