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Multifunctional macromolecules continue to attract attention. Here, three generations of a new family of bifunctional organoiron dendrimers are reported, which are synthesized from a redox-active organoiron complex, η6-dichlorobenzene-η5-cyclopentadienyl-iron(II). The facile chemistry of the compl...
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A bacterial strain designated RKEM611T was isolated from the gorgonian octocoral Antillogorgia elisabethae, collected off the coast of San Salvador, The Bahamas. The strain was Gram-negative, an obligate aerobe, and pleomorphic. It required NaCl for growth and exhibited optimal growth at 1-2% (w/v) ...
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We report here the draft genome sequence of Kitasatospora griseola strain MF730-N6, a known producer of bafilomycin, terpentecin, and satosporins. The current assembly comprises 8 contigs covering 7.97 Mb. Genome annotation revealed 7,225 protein coding sequences, 100 tRNAs, 40 rRNA genes, and 23 se...
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Nanocomposites containing ionically-conductive polymers are of interest due to potential applications as solid electrolytes for lithium–ion batteries. This paper reports intercalation of varying mole ratios of poly[oxy-methylene-(oxyethylene)] into lithium hectorite. The resulting nanocomposites w...
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Previous work in our laboratory demonstrated the utility of synthetic combinations of two naturally occurring, biologically active compounds. In particular, we combined two known anti-oxidant compounds, lipoic acid and apocynin, covalently linked via an ester bond (named UPEI-100). In an animal mode...
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Oil sands-influenced process waters have been observed to cause reproductive effects and to induced CYP1A activity in fishes; however, little progress has been made in determining causative agents. Naphthenic acids (NAs) are the predominant organic compounds in process-affected waters, but due to th...
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Two novel β-lactone-containing natural products, cystargolides A (1) and B (2), were isolated from the actinomycete Kitasatospora cystarginea. The production of these two natural products was highlighted using a methodology associating liquid chromatography-high-resolution mass spectrometry (LC-HRM...
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The corrosion inhibitor 5-tolyltriazole (5-TTri) can have a detrimental impact on aquatic systems thus implying an acute need to reduce the effluent concentrations of 5-TTri. In this study, 5-TTri biodegradation was enhanced through acclimation and nutrient supply. Activated sludge communities (ASC)...
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Edaravone, an electron spin trapper with radical scavenging activity, has been shown to be effective in reducing infarct volume in humans following ischemic stroke. However, concerns of edaravone-induced renal toxicity have limited its clinical adoption. Previous work has demonstrated that edaravone...
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Protein tyrosine phosphatases (PTPs) play an essential role in maintaining the proper tyrosine phosphorylation state of proteins. Abnormal tyrosine phosphorylation has been implicated in diseases as diverse as type 2 diabetes, cancer, immune disorders and neurological disorders, and thus inhibitors ...
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Polyaniline, poly( N-methyl aniline), poly(2-ethyl aniline) and poly(2-propyl aniline) were intercalated into layered molybdenum diselenide by using the exfoliation/restacking property of LiMoSe. MoSe was reacted with n-butyllithium to form LiMoSe. The LiMoSe was exfoliated in N-methylformamide (NMF...
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The reaction of dichloro-terminated organoiron complex [Fe(1,4-C6H4Cl2)Cp]+PF6- (3) with 4-hydroxybenzoic acid resulted in the formation of dicarboxylic acid organoiron complex 4. 4′-Hexyl alcohol-2,2′:6′,2″-terpyridine (hextpy) 2 was reacted with dicarboxylic acid organoiron complex 4 or th...
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Due to a rate increase in the resistance of microbial pathogens to currently used antibiotics, there is a need in society for the discovery of novel antimicrobials. Historically, fungi are a proven source for antimicrobial compounds. The main goals of this study were to investigate the fungal divers...
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The corrosion inhibitor 5-tolyltriazole (5-TTri) can have a detrimental impact on aquatic systems thus implying an acute need to reduce the effluent concentrations of 5-TTri. In this study, 5-TTri biodegradation was enhanced through acclimation and nutrient supply. Activated sludge communities (ASC)...
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Natural products and their mimics have a high probability of engaging with biological targets. Hence, natural products have historically been a valuable source of medicines. They continue to inspire the synthesis of biologically relevant compound libraries, useful for drug discovery. Over 50 % of th...
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We present an application of the recently introduced Localized Pair Model (LPM) [Z. A. Zielinksi and J. K. Pearson, Comput. Theor. Chem., 2013, 1003, 7990] to characterize and quantify properties of the chemical bond in a series of substituted benzoic acid molecules. By computing interelectronic dis...
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The octocoral-derived terpenes fuscol and eunicol are known, potent anti-inflammatory agents. While total syntheses of one of the parent natural products have been published, the economic and practical feasibility of producing commercially viable amounts of material is very low. Based on the observa...
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Marine sediments from Newfoundland, Canada were explored for biotechnologically promising Actinobacteria using culture-independent and culture-dependent approaches. Culture-independent pyrosequencing analyses uncovered significant actinobacterial diversity (H′—2.45 to 3.76), although the taxonom...
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Sandwich complexes-containing polymers are attractive complements of organic-based polymers as the former feature intriguing properties. These include excellent thermal stability, redox activity, magnetic, electrical, and optical properties. This review surveys many of the synthetic approaches that ...
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A new lipopeptide, cystargamide (1) was isolated from the fermentation broth of the actinomycete Kitasatospora cystarginea. The bacterial strain was selected from a set of 12 Kitasatospora spp. using a secondary metabolomics approach combining liquid chromatography/high-resolution mass spectrometry ...
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Actinomycetes are an important resource for the discovery of natural products with therapeutic properties. Bioprospecting for actinomycetes typically proceeds without a priori knowledge of the bacterial diversity present in sampled habitats. In this study, we endeavored to determine if overall bacte...
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The present study demonstrates the benefits of combinatorial antioxidant therapy in the treatment of ischemic stroke. Male Sprague-Dawley rats were anaesthetised and the middle cerebral artery (MCA) was occluded for 30 minutes followed by 5.5 hours of reperfusion. Pretreatment with resveratrol 30 mi...