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[Page generation failure. The bibliography processor requires a browser with Javascript enabled.] Immunological (ovalbumin) and non-immunological (calcium ionophore A23187) stimulation of guinea pig trachea induces a prolonged contraction that is enhanced by indomethacin (8.5 microM) and inhibited by nordihydroguaiaretic acid (50 microM) pretreatment of the tissue. The mediator released by the a...  |
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[Page generation failure. The bibliography processor requires a browser with Javascript enabled.] Antigen challenge in vivo of rat peritoneal cells (enriched with monocytes and polymorphonuclear leucocytes) passively sensitized 2 h previously with homologous antibody of the IgGa class released large amounts of slow-reacting substance of anaphylaxis (SRS-A, 1739 +/- 59 u/ml) into the peritoneal f... |
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.] The role of prostaglandins (PG) in the pulmonary hypertension associated with high-frequency oscillatory ventilation (HFOV) was investigated in 7 pentobarbital-anesthetized dogs. The magnitude and time course of the mean pulmonary artery pressure (PAP) changes induced by HFOV (20 Hz) was quantified ... |
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[Page generation failure. The bibliography processor requires a browser with Javascript enabled.] The immunological release of slow-reacting substance of anaphylaxis (SRS-A) from bovine lung is modulated by several autonomic and autacoid agents. Isoproterenol, a beta-adrenergic agonist, inhibited release of SRS-A, as did cyclic AMP. Phenylephrine also inhibited SRS-A release but through alpha-ad... |
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.] Both antigen- and calcium ionophore A23187-induced airways contractions are dependent on increased concentrations of free intracellular calcium. Antigen, but not A23187, contracted airways in the absence of extracellular calcium, suggesting that antigen-induced airways contraction was partly depende... |
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[Page generation failure. The bibliography processor requires a browser with Javascript enabled.] Both antigen- and calcium ionophore A23187-induced airways contractions are dependent on increased concentrations of intracellular calcium. Challenge of isolated tracheal spirals and parenchymal strips from sensitized guinea pigs with antigen or calcium ionophore A23187 in the presence of the intrac... |
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.] Ovalbumin (OA) and calcium ionophore A23187 were used to induce contractions of sensitized guinea-pig tracheal and lung parenchymal preparations in the presence and absence of indomethacin. This model was used to examine the properties of a series of compounds reported to inhibit 5-lipoxygenase or t... |
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.] Large-conductance calcium-dependent potassium (maxi-K) channels play an important role in regulating the tone of airway smooth muscle and the release of bronchoconstrictive substances from nerves in the lung. Crude extracts of Desmodium adscendens, a medicinal herb used in Ghana as a treatment for a... |