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Ovalbumin (OA) and the calcium ionophore A23187 induced a dose-dependent contraction of guinea pig tracheal strips. The OA-induced contraction (of sensitized trachea) consisted of an initial peak concentration, maximal between 5 and 10 min, followed by a very gradual decline from the peak. On the ot...
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Bovine slow-reacting substance of anaphylaxis (SRS-A) is capable of producing dose-dependent vascular permeability changes in the skin of calves. The wheals are well-defined indurations, similar to wheals induced by histamine but different from those induced by prostaglandin E2 (PGE). Three proposed...
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Antigen challenge in vivo of rat peritoneal cells (enriched with monocytes and polymorphonuclear leucocytes) passively sensitized 2 h previously with homologous antibody of the IgGa class released large amounts of slow-reacting substance of anaphylaxis (SRS-A, 1739 +/- 59 u/ml) into the peritoneal f...
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A ninhydrin positive compound (L2) now identified as 2-amino-5-(N-ethylcarboxyamido)-pentanoic acid, from unprocessed tea leaves was a potent inhibitor of thrombin-stimulated thromboxane formation in rabbit whole blood (Ali and Afzal; Prostaglandins, Leukotrienes and Medicine, 27: 9, 1987). In the p...
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Experiments were conducted to examine the variability between Atlantic salmon parr acclimated to 7 degrees C (n=150) and those acclimated to 14 degrees (n=150) over a year. Fish were stocked into tanks (2.32 x 2.32 x 0.52 m) at 10.5 kg/msuperscript 3. The condition factor remained similar for both g...
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13th Annual Meeting of the Aquaculture Association of Canada, Ottawa, Ont., June 4.
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7th Annual APICS Aquaculture Conf., Truro, NS., March 8
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14th Annual Meeting of the Aquaculture Association of Canada, Quebec City, June 10-12
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Medetomidine proved to be an effective sedative in rainbow trout but not an anaesthetic; its effects were antagonized by atipamezole. The clinical signs of medetomidine sedation were rapid settling to the bottom of the tank followed by progressive ataxia. The sedative effect was dose-dependent: at 1...
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Large-conductance calcium-dependent potassium (maxi-K) channels play an important role in regulating the tone of airway smooth muscle and the release of bronchoconstrictive substances from nerves in the lung. Crude extracts of Desmodium adscendens, a medicinal herb used in Ghana as a treatment for a...
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Mellavax (avirulent S. dublin vaccine) appears to cause an anaphylactoid reaction in a ratio of 1:28 000 doses sold. A clinical picture of respiratory embarrassment and pulmonary oedema occurs. Histamine, 5-HT and dopamine are implicated mediators released during the reaction but to a minor extent c...
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Ovalbumin induces contraction of sensitized guinea-pig trachea, both in the presence and absence of indomethacin. Cascade superfusion bioassay was employed to detect mediator release. A prostaglandin E-like material was released in response to antigen in the absence of indomethacin but, no biologica...
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