Results

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Examined, in 9 normal volunteers (mean age 33.1 yrs), the in vitro effects of moclobemide on the production of interleukin-6 (IL-6), IL-8, tumor necrosis factor-? (TNF?), interferon-? (IFN?), IL-10 and the IL-1 receptor antagonist (IL-1RA) by diluted whole blood stimulated or not with lipopolysaccha...
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No Abstract
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Reviews the book, Human Psychoneuroimmunology edited by K. Vedhara and M. Irwin (2005).
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the effect of subacute intracerebroventricular (icv 0.1, 0.5, and 1.0 mg) administration of corticotropin-releasing factor (CRF) for 5 days on behavior, neurotransmitter concentrations, and immune functions was studied in rats / sought to address 2 important questions: (1) do the effects of icv admi...
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Interleukin (IL)-1beta is a pro-inflammatory cytokine involved in modulating inflammation and stress responses in the brain. Central administration of IL-1beta impairs both memory functions and long-term potentiation (LTP) induction. However, the molecular events responsible for the downstream effec...
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The effects of academic examination stress (AES) on serum concentrations of interleukin (IL)-1 receptor (R) antagonist (A), solubles IL-2R, sIL-6R, soluble glycoprotein 130 (sgp130), Clara cell protein (CC16), sCD8 and sCD14 were evaluated in 38 Ss (ages 19-22). Also examined were relationships amon...
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Reviews 131 studies, published since 1967, to address the effects of olfactory bulbectomy (OB) and drug treatments on immune system, neurotransmitters, and behavior in rats.
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Previously, we have reported that interleukin-1 beta (IL-1) induces changes in dopaminergic (DA) and serotonergic systems in the core of nucleus accumbens (NAc). We have also demonstrated that n-3 fatty acid ethyl-eicosapentaenoate (EPA) can significantly reduce stress and anxiety-like behaviors, co...
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BACKGROUND: Animal studies have demonstrated seasonal changes in immune function mediated by nocturnal melatonin duration as a biological signal for photoperiod. Recent research has highlighted the potential role of neuroimmune dysfunction in depressive disorders. The etiology of winter depression (...
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The bacterial endotoxin lipopolysaccharide (LPS) produces a host of effects in mammals known collectively as 'sickness' behaviours. Acute treatment with LPS also results in a loss of hedonic capacity in rodents that can be measured by changes in responding for reinforcing electrical stimulation of t...
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Thymectomized male rats showed a significant impairment in learning and memory as shown by deficits in passive avoidance and in the Morris water maze test. Following treatment for 20 days with either piracetam or tacrine, the deficit in passive avoidance learning was largely reversed.
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Used the olfactory-bulbectomized rat model of depression to examine relationships between cellular enzyme activities and neutrophil phagocytic response in male rats and to determine how chronic LiCl treatment reverses impaired phagocytic response in neutrophils of the bulbectomized rat.
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Reviews the book, Psychology edited by Miles Hewstone, Frank D. Fincham, and Jonathan Foster (2005).
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Examined the effects of subchronically administered neuropeptide Y (NPY) intracerebroventricular/ly (icv) on behavioral, neurochemical, and immunological parameters in the olfactory bulbectomized (OB) rat model of depression.
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Evidence suggests a link between Parkinson's disease and the dietary intake of omega (n)−3 and n−6 polyunsaturated fatty acids (PUFAs). Presently, we investigated whether an acute dose of parkinsonian neurotoxin 1-methyl-4-phenylpyridinium (MPP+) affects brain n−3 and n−6 PUFA content a...
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Interleukin (IL)-1beta may play an important role in Alzheimer's disease. However, the relationships between glucocorticoids and acetylcholine (ACh), and between neurotrophins and ACh in IL-1-induced memory deficits are unknown. While ethyl-eicosapentaenoate (E-EPA) has recently been reported t...
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Examined the in vitro effects of lithium carbonate on the unstimulated and lipolysaccharide (LPS)?+?phytohemagglutinin (PHA)-induced production of proinflammatory cytokines, such as interleukin-6 (IL-6), IL-8, tumor necrosis factor-? (TNF?) and interferon-? (IFN?), and negative immunoregulatory cyto...
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Hypothalamic paraventricular nucleus (PVN) is one of the main sources of arginine vasopressin (AVP) synthesis and secretion. AVP is the most important bioactive substance in PVN regulating pain process. Our pervious study has pointed that pain stimulation induced AVP increase in the nucleus raphe ma...
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S100B is a calcium-binding protein, which is produced primarily by glial cells. It modulates the proliferation and differentiation of neurons and glia by affecting protective and apoptotic mechanisms. Recently, several studies have shown increased serum S100B levels in patients with schizophrenia, s...
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Bilateral olfactory bulbectomy results in changes in behavior, and in the endocrine, immune and neurotransmitter systems, that simulates many of those seen in patients with major depression. The olfactory system in the rat forms a part of the limbic region in which the amygdala and hippocampus contr...
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Omega (n)-3 and n-6 fatty acids are important membrane components of neurons and immune cells, and related to psychiatric and inflammatory diseases. Increased ratio of n-6/n-3 in the blood has been reported in depressed patients and in students following stress exposure. The n-3 fatty acid, eicosape...
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The present study demonstrated that an omega (n)-3 fatty acid, ethyl-eicosapentaenoic acid (ethyl-EPA), supplemented diet significantly attenuated the stress/anxiety behavior of rats in the "open field" and elevated plus maze, which was induced by subchronic intracerebroventricular adminis...
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Reviews the interaction between anxiety and the immune system and modulating effects of benzodiazepines. Research indicates that anxiety induces immune-inflammatory changes pointing toward the complex regulatory responses in interleukin-6 signalling, decreased anti-inflammatory capacity of the serum...