Assessed the effect of chronic (3 mmol/kg for 15 days) lithium chloride (Li) on open field activity and immune function in bilaterally olfactory bulbectomized and sham-operated male rats. Li did not reverse the hyperactivity of the bulbectomized rats (BRs) and did not affect growth rate significantl...

Examined, in 9 normal volunteers (mean age 33.1 yrs), the in vitro effects of moclobemide on the production of interleukin-6 (IL-6), IL-8, tumor necrosis factor-? (TNF?), interferon-? (IFN?), IL-10 and the IL-1 receptor antagonist (IL-1RA) by diluted whole blood stimulated or not with lipopolysaccha...

the effect of subacute intracerebroventricular (icv 0.1, 0.5, and 1.0 mg) administration of corticotropin-releasing factor (CRF) for 5 days on behavior, neurotransmitter concentrations, and immune functions was studied in rats / sought to address 2 important questions: (1) do the effects of icv admi...

Reviews the book, Human Psychoneuroimmunology edited by K. Vedhara and M. Irwin (2005).

Reviews 131 studies, published since 1967, to address the effects of olfactory bulbectomy (OB) and drug treatments on immune system, neurotransmitters, and behavior in rats.

Used the olfactory-bulbectomized rat model of depression to examine relationships between cellular enzyme activities and neutrophil phagocytic response in male rats and to determine how chronic LiCl treatment reverses impaired phagocytic response in neutrophils of the bulbectomized rat.

Reviews the book, Psychology edited by Miles Hewstone, Frank D. Fincham, and Jonathan Foster (2005).

Examined the effects of subchronically administered neuropeptide Y (NPY) intracerebroventricular/ly (icv) on behavioral, neurochemical, and immunological parameters in the olfactory bulbectomized (OB) rat model of depression.

Evidence from clinical studies suggests that chronic exposure to physical and/or psychological stress profoundly affects the mental state and may be causally involved in anxiety and depressive disorders.

This review attempts to critically assess the interplay between CRF, the immune and neurotransmitter systems, and behavior in chronic stress and depression.

Examined the serum concentration of corticosterone, neutrophil phagocytosis, lymphocyte proliferation, leucocyte adhesiveness/aggregation (LAA), and differential white blood cell (WBC) count in 50 male rats following exposure to the behavioral despair and open-field tests.

Examined the effects of academic examination stress on leukocyte and lymphocyte subset distribution in university students.

Examined the production of interferon-?, tumor necrosis factor-? (TNF-?), granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin-6 (IL-6), IL-10, IL-4, IL-5, IL-1 receptor antagonist (IL-IRA), and prostaglandin E-sub-2 in relation to the number of leukocytes in the blood of detoxifie...

Examined the effects of academic examination stress, on total serum protein (TSP) and patterns obtained in serum protein electrophoresis. TSP and the concentrations and percentages of the major electrophoretically separated serum proteins were measured in 41 healthy biomedical students (aged 19-22 y...

Thymectomized male rats showed a significant impairment in learning and memory as shown by deficits in passive avoidance and in the Morris water maze test. Following treatment for 20 days with either piracetam or tacrine, the deficit in passive avoidance learning was largely reversed.

Examined the in vitro effects of lithium carbonate on the unstimulated and lipolysaccharide (LPS)?+?phytohemagglutinin (PHA)-induced production of proinflammatory cytokines, such as interleukin-6 (IL-6), IL-8, tumor necrosis factor-? (TNF?) and interferon-? (IFN?), and negative immunoregulatory cyto...

Examined immune-deficiency markers, i.e., serum interleukin-6 (IL-6), IL-8, IL-6 receptor (IL-6R), IL-1R antagonist (IL1RA), gp130, and prostaglandin E2 (PGE2) production by mitogen-stimulated whole blood and the availability of plasma tryptophan in 10 patients with primary sleep disorders, 6 patien...

It has been reported that activation of the inflammatory response system (IRS) may play a role in the aging process and in the pathogenesis of the degenerative changes associated with dementia of the Alzheimer type (DAT). This study examined the peripheral IRS in 31 normally aging Ss (age 22-91 yrs)...

There is some evidence that antipsychotic drugs may have immunosuppressive effects. This study examined the in-vitro effects of different concentrations of antipsychotic agents on cytokine production by human whole blood.

The olfactory bulbectomized (OB) rat has been developed as an animal model of depression. In the novel "open field" environment, male OB rats showed a hyperactivity which was attenuated by chronic treatment with desipramine (7.5 mg/ kg) for 20 days. Neutrophil phagocytosis was suppressed by the lesi...

Variations of plasma ACTH and corticosterone, splenic macrophage activity, and mitogen-induced cell proliferation were determined in male rats following 15 min of either neurogenic stress (restraint) or psychogenic stress (exposure to a ferret). The effects of these stressors were assessed in 2 stra...

Examined whether cell proliferation in response to mitogens, natural killer cell (NK) activity, and macrophage functioning of mice may be influenced by either a neurogenic stressor (footshock) or psychogenic stressor (exposing the mouse to a predator, namely a rat).

The effects of academic examination stress (AES) on serum concentrations of interleukin (IL)-1 receptor (R) antagonist (A), solubles IL-2R, sIL-6R, soluble glycoprotein 130 (sgp130), Clara cell protein (CC16), sCD8 and sCD14 were evaluated in 38 Ss (ages 19-22). Also examined were relationships amon...

Our previous study has pointed that arginine vasopressin (AVP) and norepinephrine (NA) are two most important bioactive substances that play a role in hypothalamic paraventricular nucleus (PVN) regulating pain process. The communication was designed to investigate the interaction between AVP and NA ...