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Background In the last two decades, many studies have found that neuroinflammation is causally related to the onset [...] Background In Alzheimer?s disease, stroke and brain injuries, activated microglia can release proinflammatory cytokines, such as interleukin (IL)-1[beta]. These cytokines may cha...
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Background: In Alzheimer's disease, stroke and brain injuries, activated microglia can release proinflammatory cytokines, such as interleukin (IL)-1β. These cytokines may change astrocyte and neurotrophin functions, which influences neuronal survival and induces apoptosis. However, the interaction ...
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Reviews the interaction between anxiety and the immune system and modulating effects of benzodiazepines. Research indicates that anxiety induces immune-inflammatory changes pointing toward the complex regulatory responses in interleukin-6 signalling, decreased anti-inflammatory capacity of the serum...
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Hypothalamic paraventricular nucleus (PVN) is one of the main sources of arginine vasopressin (AVP) synthesis and secretion. AVP is the most important bioactive substance in PVN regulating pain process. Our pervious study has pointed that pain stimulation induced AVP increase in the nucleus raphe ma...
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Monoamine oxidase (MAO) A is a critical enzyme in the catabolism of dopamine. Dysfunction of dopaminergic systems has been implicated in the pathophysiology of schizophrenia, suggesting that MAOA gene variation might be associated with the disorder. MAOA gene variation was compared between 234 Chine...
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Three common dosing regimens of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced model of Parkinson's disease (PD) were compared in C57BL/6 mice on behavior, striatal and extra-striatal neurotransmission, and brain cytokines, to clarify the differences between regimens on these v...
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the effect of subacute intracerebroventricular (icv 0.1, 0.5, and 1.0 mg) administration of corticotropin-releasing factor (CRF) for 5 days on behavior, neurotransmitter concentrations, and immune functions was studied in rats / sought to address 2 important questions: (1) do the effects of icv admi...
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Examined the effects of chronic treatment with non-sedative histamine H-sub-1 receptor antagonist terfenadine on the behavioral and immunological parameters in the olfactory bulbectomized (OB) rat model of depression. OB Sprague-Dawley rats were injected with saline or terfenadine for 16 days after ...
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Used the olfactory-bulbectomized rat model of depression to examine relationships between cellular enzyme activities and neutrophil phagocytic response in male rats and to determine how chronic LiCl treatment reverses impaired phagocytic response in neutrophils of the bulbectomized rat.
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The olfactory bulbectomized (OB) rat has been developed as an animal model of depression. In the novel "open field" environment, male OB rats showed a hyperactivity which was attenuated by chronic treatment with desipramine (7.5 mg/ kg) for 20 days. Neutrophil phagocytosis was suppressed by the lesi...
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Examined the concentrations of immunoglobulin IgM, complement C3c, complement C4, positive acute phase proteins (e.g., haptoglobin, ?-sub-1-acid glycoprotein, ?-sub-1-antitrypsin), and negative acute phase proteins (e.g., albumin, transferrin) in 20 unipolar depressed patients and 8 healthy controls...
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This review summarizes some of the evidence which implicates an increase in the peripheral and central secretion of pro-inflammatory cytokines in the behavioural changes seen in some stress-induced and brain lesion models of depression. Following a consideration of the role of cytokines in the perip...
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Evidence from clinical studies suggests that chronic exposure to physical and/or psychological stress profoundly affects the mental state and may be causally involved in anxiety and depressive disorders.
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Examined the production of interferon-?, tumor necrosis factor-? (TNF-?), granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin-6 (IL-6), IL-10, IL-4, IL-5, IL-1 receptor antagonist (IL-IRA), and prostaglandin E-sub-2 in relation to the number of leukocytes in the blood of detoxifie...
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Omega (n)-3 and n-6 fatty acids are important membrane components of neurons and immune cells, and related to psychiatric and inflammatory diseases. Increased ratio of n-6/n-3 in the blood has been reported in depressed patients and in students following stress exposure. The n-3 fatty acid, eicosape...
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BACKGROUND: Animal studies have demonstrated seasonal changes in immune function mediated by nocturnal melatonin duration as a biological signal for photoperiod. Recent research has highlighted the potential role of neuroimmune dysfunction in depressive disorders. The etiology of winter depression (...
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Examined the effects of the chronic administration of the sigma ligand JO 1784 (igmesine) CRF-induced changes in some behavioural, immune, endocrine and neurotransmitter parameters in rats.
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Thymectomized male rats showed a significant impairment in learning and memory as shown by deficits in passive avoidance and in the Morris water maze test. Following treatment for 20 days with either piracetam or tacrine, the deficit in passive avoidance learning was largely reversed.
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The present study demonstrated that an omega (n)-3 fatty acid, ethyl-eicosapentaenoic acid (ethyl-EPA), supplemented diet significantly attenuated the stress/anxiety behavior of rats in the "open field" and elevated plus maze, which was induced by subchronic intracerebroventricular adminis...
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Background The n-3 polyunsaturated fatty acid, eicosapentaenoic acid (EPA) has been found to process neuroprotective effects. However, the exact cellular mechanisms are not well understood. Brain-derived neurotrophic factor (BDNF) is one of neurotrophins, which is involved in neuron differentiation,...
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