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Mussel (Mytilus edulis) culture in Atlantic Canada utilizes wild seed harvested from spat collection sites. The economics associated with wild-caught seed have proven to be more favourable than with hatchery-produced seed. This is not, however, the case in all areas. In Washington state, seed used f...
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The toxicity of BMS-182248, an immunoglobulin (cBR96)-cytotoxic drug (doxorubicin) conjugate, was investigated in Sprague-Dawley rats at single intravenous doses of 508, 1,200, and 2,550 mg/m(2) (conjugated doxorubicin doses of 14.7, 34.8, and 74 mg/m(2), respectively) and compared to that obtained ...
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The development of effective mitigation techniques against Botryllus schlosseri and Botrylloides violaceus colonizing blue mussel
aquaculture operations has not been well studied. The objectives of our research were to determine the efficacy of using pressurized seawater
in the mitigation ...
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Oncostatin M (OM) is a member of the interleukin-6 (IL-6) cytokine subfamily. The binding of OM to its receptor initiates signal transduction through JAK-signal transducers and activators of transcription (STAT) pathways and activates transcription activators through mitogen-activated protein (MAP) ...
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The study of protein function in neurons has been hindered by the lack of highly efficient, nontoxic methods of inducing RNA interference in such cells. Here we show that application of synthetic small interfering RNA( siRNA) linked to the vector peptide Penetratin1 results in rapid, highly efficien...
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BR96 sFv-PE40, a recombinant DNA-derived fusion protein composed of the heavy- and light-chain variable region domains of the monoclonal antibody BR96 and the translocation and catalytic domains of Pseudomonas exotoxin A, is being developed for the treatment of solid tumors expressing cell surface L...
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In 1999, examination of soft-shell clam (Mya arenaria) mortalities at an experimental lease on Prince Edward Island (PEI) revealed a 95% prevalence of advanced haemic neoplasia (leukaemia). Low prevalences of this condition had been documented previously in soft-shell clams from Nova Scotia and the ...
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Spatial growth variation of experimentally cultured blue mussels Mytilus edulis in Tracadie Bay, Prince Edward Island, Canada, was consistent in both years of a 2 yr study. The spatial pattern displayed reduced tissue growth along a gradient of decreasing tidal exchange from the inlet mouth to the i...
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Owners of 141 dairy herds who used the Dairy Herd Improvement Association's database for keeping production and reproduction records were interviewed to describe the location of fans, shade structures, and sprinklers on their farms. Production and reproduction data were retrieved from the database, ...
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Mussel growers in Prince Edward Island (PEI), Canada, currently use high-pressure water spraying (~700 psi) to mortally injure
or dislodge invasive tunicates from mussel product and gear. An added benefit of this process may be the stimulation of byssal
thread production, leading to improv...
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Some 20 male New Zealand White rabbits (five/group) were given either didanosine (ddl) or stavudine (d4T) at 750 and 1500 mg/kg body weight/day by oral intubation for 24 wk. An additional group was given 300 mg/kg body weight/day zidovudine (AZT) as a negative control. After 13 weeks the high dose o...
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Cetylpyridinium chloride (CPC) is a quaternary ammonium salt and cationic surfactant. It has been used as a biocide in personal hygiene products and a charge control additive in some reprographic toners. CPC is orally toxic to rats, mice and rabbits and can cause severe eye irritation. Acute inhalat...
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G28-5 sFv-PE40 is a single-chain immunotoxin targeted to CD40, which is highly expressed on human hematologic malignancies, including non-Hodgkin's lymphoma, B-lineage leukemias, multiple myeloma, and Hodgkin's disease, as well as certain carcinomas. In vitro analysis showed that this monovalent imm...
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The induction of triploidy in Mytilus edulis, using 6-dimethylaminopurine (6-DMAP), was investigated as a potential method of providing high quality sterile product in Prince Edward Island (PEI), Canada. Initial results indicated induction by blocking the second polar body would require a treatment ...
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The aetiology of haemic neoplasia (HN) is unknown, so far but many causative factors are suggested such as viral, pollution and genetics. The aim of this study was to determine if, under chronic exposure, two major pesticides (chlorothalonil and mancozeb) which are used in potato production could in...