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Mussel (Mytilus edulis) culture in Atlantic Canada utilizes wild seed harvested from spat collection sites. The economics associated with wild-caught seed have proven to be more favourable than with hatchery-produced seed. This is not, however, the case in all areas. In Washington state, seed used f...
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The toxicity of BMS-182248, an immunoglobulin (cBR96)-cytotoxic drug (doxorubicin) conjugate, was investigated in Sprague-Dawley rats at single intravenous doses of 508, 1,200, and 2,550 mg/m(2) (conjugated doxorubicin doses of 14.7, 34.8, and 74 mg/m(2), respectively) and compared to that obtained ...
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The development of effective mitigation techniques against Botryllus schlosseri and Botrylloides violaceus colonizing blue mussel
aquaculture operations has not been well studied. The objectives of our research were to determine the efficacy of using pressurized seawater
in the mitigation ...
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Oncostatin M (OM) is a member of the interleukin-6 (IL-6) cytokine subfamily. The binding of OM to its receptor initiates signal transduction through JAK-signal transducers and activators of transcription (STAT) pathways and activates transcription activators through mitogen-activated protein (MAP) ...
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The study of protein function in neurons has been hindered by the lack of highly efficient, nontoxic methods of inducing RNA interference in such cells. Here we show that application of synthetic small interfering RNA( siRNA) linked to the vector peptide Penetratin1 results in rapid, highly efficien...
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BR96 sFv-PE40, a recombinant DNA-derived fusion protein composed of the heavy- and light-chain variable region domains of the monoclonal antibody BR96 and the translocation and catalytic domains of Pseudomonas exotoxin A, is being developed for the treatment of solid tumors expressing cell surface L...
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