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A 13-year-old, neutered male domestic cat presented with signs of weight loss, anemia, and hepatomegaly. Pathognomonic signs of porphyria were identified. Charcoal-like renal calculi and severe liver changes were observed, neither of which has been previously reported in association with feline ...
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Both prokaryotes and eukaryotes express a set of highly conserved proteins in response to external and internal stress. The stressors include tissue trauma, anoxia, heavy metal toxicity, infection, changed salinity, and the most characterized, heat shock. The result is an expression of stress protei...
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In vitro evidence of the involvement of the endoplasmic reticulum (ER) during drug-induced renal toxicity is accumulating. ER stress and ER-mediated cell death markers have been reported after exposure of renal cells to model toxicants and nephrotoxic drugs in various in vitro models, but in vivo ex...
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Several models of anthrax pathogenesis suggest that early in the infectious process Bacillus anthracis endospores germinate and outgrow into vegetative bacilli within phagocytes before being released into the blood. Here, we define the respective contributions of three phospholipases C (PLCs) to the...
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p-Aminophenol (pAP, 225 mg/kg) administration to rats induced renal failure and has been associated with markers of endoplasmic reticulum (ER) stress, as well as calpain and caspase-12 activation in kidneys. To determine the importance of ER stress and calpain during pAP-induced nephrotoxicity, rats...
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Wistar, Sprague-Dawley, and Long-Evans outbred rats, and the Fischer344 inbred strain were inoculated intranasally with 10superscript 3 TCID50 of sialodacryoadenitis virus at approximately 9 weeks of age. Paired animals were killed at 2-day intervals after inoculation up to 2 weeks, then at 20 days....
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Rats treated with prednisolone (PR) or cyclophosphamide (CY) and inoculated intranasally with sialodacryoadenitis (SDA) virus were compared with nonimmunosuppressed, inoculated rats. Histological changes in salivary and lacrimal glands, immunofluorescent microscopy of paraffin-embedded tissues, seru...
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Ninety-six (4/dog) percutaneous transabdominal hepatic needle biopsy specimens were obtained from 24 dogs each weighing 10 to 24 kg. Two biopsies were performed in each dog before and 5 days after hepatopathy was experimentally induced. The difficulties encountered in obtaining hepatic tissue are re...
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The Bacillus anthracis chromosome encodes four unique, putative superoxide dismutase (sod) genes. During exponential growth and sporulation, sodA1, sodA2, and sodC are transcribed constitutively throughout the growth cycle as individual genes. In contrast, the transcription of sod15 occurs mainly du...
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A 1-year-old male Cairn Terrier was evaluated for chronic coughing that was aggravated by eating or drinking. Radiography revealed an esophageal diverticulum, regional megaesophagus, and focal interstitial densities in the right caudal and middle lung lobes. Using fluoroscopy and contrast radiograph...
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A rapid gross visual appraisal of enzootic pneumonia lesions was made of 87 lungs at a local abattoir and the lungs were then set aside and examined in more detail. A sample of pulmonary tissue was taken from each lung and submitted for bacterial and histological examination. The principal investiga...
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This study was carried out to determine the diagnostic usefulness of postmortem eyefluid analysis in estimating antemortem concentrations of serochemical constituents. A total of 31 cattle, 18 dogs and 22 cats were selected from routine elective euthanasia submissions to a diagnostic laboratory. For...
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Calcinosis circumscripta is an uncommon syndrome of ectopic idiopathic, dystrophic, metastatic or iatrogenic mineralization characterized by deposition of calcium salts in soft tissues. This paper is a retrospective study of 77 canine cases. The age of dogs in the study varied from 4 months to 15 ye...
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This report identifies and genotypes the bovine viral diarrhoea virus (BVDV) in up to 20 years old archival formalin fixed paraffin embedded (FFPE) tissues of bovine foetuses and calves. Samples from 6 presumably BVDV aborted foetuses and 3 calves diagnosed with mucosal disease were tested by immu- ...
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Five cases of hypoadrenocorticism in young related Nova Scotia duck tolling retrievers are discussed. Two were littermates and the others shared one or more common ancestors. No specific mode of inheritance was determined. Clinical and laboratory findings typical of hypoadrenocorticism were observed...
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We evaluated the effects of immunostimulation in the development of postweaning multisystemic wasting syndrome (PMWS) in 930 pigs 53 to 54 d old in a grower/finisher barn with a history of PMWS. The pigs were allocated to 5 treatment groups: 4 groups received a single intramuscular injection of Resp...
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A 1.5-year-old dog was evaluated for abnormal mentation, collapse, and weight loss. Radiographs and ultrasonographs revealed soft tissue masses in the mid abdomen. Ultrasound-guided fine-needle aspirates provided a diagnosis of malignant epithelial or round cell neoplasia. Histopathologic and immuno...
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The prevalence of Mycobacterium avium ssp. paratuberculosis (Mptb) in culled dairy cattle in Eastern Canada and Maine was determined to be 16.1% (95% confidence interval 13.8 to 18.3%) based on a systematic random sample of abattoir cattle. Mesenteric lymph nodes and ileum from 984 cows were examine...
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Paired samples of formalin-fixed, paraffin-embedded ileum and lymph node from 204 culled dairy cows were investigated for evidence of infection by Mycobacterium avium subsp. paratuberculosis. Of the samples, 151 were from animals that were tissue-culture positive for M. avium subsp. paratuberculosis...
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