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5-Hydroxytryptamine (serotonin, 5-HT) increased the release of endogenous adenosine from dorsal, but not ventral, spinal cord synaptosomes. This release was reduced by (i) the 5-HT receptor antagonist methysergide, (ii) removal of Ca2+ from the medium, (iii) inhibition of ecto-5'-nucleotidase a...
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This study was designed to examine the ability of pertussis toxin to block various responses due to (-)-baclofen in cultured cerebellar granule neurons of the rat. Treatment with pertussis toxin for 3 h markedly reduced the ability of (-)-baclofen to stimulate GTPase in membranes, and its ability to...
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