Results

[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]
Transforming growth factor-beta-1 (TGF-beta-1) stimulated DNA synthesis (3-fold) in BALBc/3T3 fibroblasts following 24 hours of growth factor exposure. Since ribonucleotide reductase is important for the coordination of DNA synthesis and cell proliferation, we investigated the hypothesis that cells ...
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]
Matrix metalloproteinase (MMP) expression was investigated in NIH-3T3 fibroblasts that secrete K-FGF and in NIH-3T3 cells which express chimeric bFGF with a signal sequence targeting bFGF to the secretory pathway. Correlations between altered MMPs' and other proteases' expression and malig...
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]
Cell growth regulation is a highly complex process. The present study demonstrates a novel link between alterations in insulin-mediated regulation during malignant conversion and the expression of S-adenosylmethionine decarboxylase, a key regulatory activity in the biosynthesis of polyamines. H-ras ...
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]
A rapid elevation of ribonucleotide reductase activity was observed with BALB c/3T3 fibroblasts treated with 10 nM okadaic acid, a nonphorbol ester tumor promoter and protein phosphatase inhibitor. Northern blot analysis of the two components of ribonucleotide reductase (R1 and R2) showed a marked e...
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]
Ribonucleotide reductase provides the four deoxyribonucleotides required for the synthesis of DNA. In this study, we examined the hypothesis that alterations in the regulation of ribonucleotide reductase activity may be necessary to provide the deoxyribonucleotides required for DNA repair, following...
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]
The hypothesis that H-ras transformed cells contain alterations in signalling pathways important in controlling the expression of S-adenosylmethionine decarboxylase, (SAMDC) a highly regulated activity in the biosynthesis of polyamines was tested. Mouse 10 T1/2 fibroblasts and H-ras transformed cell...
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]
Mammalian S-adenosylmethionine Decarboxylase (SAMDC) is a regulatory activity, which is involved in the biosynthesis of polyamines. The polyamines, namely putrescine, spermidine, and spermine, are essential for mammalian cell proliferation. SAMDC expression was examined in a H-ras transformed cell c...
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]
TGF-beta is a potent stimulator of motility in a variety of cell types. It has recently been shown that hyaluronan (HA) can directly promote locomotion of cells through interaction with the HA receptor RHAMM. We have investigated the role of RHAMM and HA in TGF-beta-stimulated locomotion and show th...
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]
The present study demonstrates alterations in the regulation of matrix metalloproteinase-2 (MMP-2) expression in response to insulin like growth factor-1 (IGF-1) in a H-ras transformed cell line, C3, which is capable of metastasis formation. These changes in MMP-2 expression in response to IGF-1 tre...
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]
Several salt compounds were tested in vitro as inhibitors of Erwinia carotovora subsp. atroseptica (van Hall) Dye (Eca) and Erwinia carotovora subsp. carotovora (Jones) Bergey, Harrison, Breed, Hammer & Huntoon (Ecc), causal agents of bacterial soft rot of potato. All compounds were mixed with p...
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]
Transforming growth factor beta(1) is an important growth regulator in many cell types, usually exerting a negative effect on cellular growth. Inhibition of DNA synthesis and cell proliferation is frequently lost during malignant transformation, and in some cases, tumor cell proliferation is actuall...
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]
Negative growth regulators such as the transforming growth factor beta (TGF-beta) family appear to be important inhibitors in most tissue types. However, inhibition of DNA synthesis and cell proliferation is frequently lost during malignant transformation, and in some cases, tumor cell proliferation...
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]
This study investigated the effects of magnolol, a compound from Magnolia officinalis, on the behavior of LNCaP and PC3 human prostate cancer cells in vitro. Materials and Methods: In vitro cell culture approach with biochemical tests and Western blot analyses was used. Results: Magnolol, (80 μM, 6...
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]
Prostate cancer is one of the most common cancers in the world, and its prevalence is expected to increase appreciably in the coming decades. As such, more research is necessary to understand the etiology, progression and possible preventative measures to delay or to stop the development of this dis...
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]
Regulation of the matrix metalloproteinases (MMPs) is crucial to regulate extracellular matrix (ECM) proteolysis which is important in metastasis. This study investigated the mechanism(s) by which three flavonoid-enriched fractions from lowbush blueberry (Vaccinium angustifolium) down-regulate MMP a...
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]
Regulation of the matrix metalloproteinases (MMPs), the major mediators of extracellular matrix (ECM) degradation, is crucial to regulate ECM proteolysis, which is important in metastasis. This study examined the effects of 3 flavonoid-enriched fractions (a crude fraction, an anthocyanin-enriched fr...
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]
Proanthocyanidin-rich extracts were prepared by fractionation of the fruit of the North American cranberry (Vaccinium macrocarpon). In vitro growth inhibition assays in eight tumor cell lines showed that selected fractions inhibited the growth of H460 lung tumors, HT-29 colon and K562 leukemia cells...
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]