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A fortified enzyme preparation of the gorgonian Pseudopterogorgia americana or Pseudopterogorgia elisabethae has been developed which efficiently transforms a variety of precursor molecules, e.g., sterols, to their corresponding metabolites, e.g., 9(11)-secosteroid in high yield. NAD, NADP, and glut...
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Natural products have long been recognized for their medicinal value in traditional medicine and remain an important component of modern drug discovery. Known for their immense structural diversity, natural products are secondary metabolites that often exhibit unique pharmacological properties. In t...
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Alcyonacean octocorals (Order Alcyonacea, amended from Order, Gorgoniidae) are both dominant on Caribbean reefs and prolific sources of bioactive natural products. Although extensive literature has been published with respect to stony coral-associated bacteria, very little is known regarding bacteri...
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The field of fungal taxonomy has been enduring in recent years due to the progress and application of molecular tools used in concert with morphological analysis. The fungal kingdom is extremely diverse and estimated to include 1.5 million species. Only 11% of these fungi are currently described in ...
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Marine invertebrates, including octocorals, are a prolific source of marine natural products (MNPs) and are also known to host diverse microbial communities. It is well-established that marine microbes are producers of bioactive secondary metabolites. Accordingly, it is hypothesized that bioactive m...
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Natural products and their mimics have a high probability of engaging with biological targets. Hence, natural products have historically been a valuable source of medicines. They continue to inspire the synthesis of biologically relevant compound libraries, useful for drug discovery. Over 50 % of th...
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The ecteinascidins are a family of tetrahydroisoquinoline alkaloids isolated from the tunicate Ecteinascidia turbinata. Ecteinascidin 743 is a candidate for the treatment of several human cancers. Ecteinascidins have been shown to kill tumor cells in vitro, inhibit tumor growth in vivo, suppress all...