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A viable cell-free extract of the marine tunicate Ecteinascidia turbinata has been generated that is capable of transforming amino acids into the ecteinascidin antitumor alkaloids. Tyrosine and cysteine were identified as two building blocks used in ecteinascidin production. The enzyme preparations ...
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Bryostatin 1, a natural product anticancer agent isolated from a marine bryozoan, has been shown in tissue culture to activate protein kinase C. This agent has recently undergone Phase I testing in humans given either as a bolus i.v. injection or a continuous infusion. To understand how bryostatin 1...
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Discovery of novel bioactive metabolites from marine bacteria is becoming increasingly challenging, and the development of novel approaches to improve the efficiency of early steps in the microbial drug discovery process is therefore of interest. For example, current protocols for the taxonomic dere...
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The field of fungal taxonomy has been enduring in recent years due to the progress and application of molecular tools used in concert with morphological analysis. The fungal kingdom is extremely diverse and estimated to include 1.5 million species. Only 11% of these fungi are currently described in ...
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Alcyonacean octocorals (Order Alcyonacea, amended from Order, Gorgoniidae) are both dominant on Caribbean reefs and prolific sources of bioactive natural products. Although extensive literature has been published with respect to stony coral-associated bacteria, very little is known regarding bacteri...
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Natural products have long been recognized for their medicinal value in traditional medicine and remain an important component of modern drug discovery. Known for their immense structural diversity, natural products are secondary metabolites that often exhibit unique pharmacological properties. In t...
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Marine invertebrates, including octocorals, are a prolific source of marine natural products (MNPs) and are also known to host diverse microbial communities. It is well-established that marine microbes are producers of bioactive secondary metabolites. Accordingly, it is hypothesized that bioactive m...
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A new lipopeptide, cystargamide (1) was isolated from the fermentation broth of the actinomycete Kitasatospora cystarginea. The bacterial strain was selected from a set of 12 Kitasatospora spp. using a secondary metabolomics approach combining liquid chromatography/high-resolution mass spectrometry ...
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Gorgonian corals continue to provide a wealth of novel structures, many of which exhibit potentially useful biological activity. Notably, the families Briareidae, Gorgoniidae and Plexauridae have been demonstrated to contain a wide variety of natural products including steroids, acetogenins, sesquit...
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Chemical studies on the non polar fraction of the methanolic extract of Pseudopterogorgia elisabethae Bayer collected from the Florida Keys has yielded 12-acetoxypseudopterolide (1), a new diterpene of the pseudopterane series. The structure was established through spectroscopic analysis. Compound (...
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Marine diterpene glycosides (MDGs) respresent a small but highly significant group of the much larger class of marine diterpenes. The three well-studied examples of MDGs are eleutherobins, pseudopterosins and fuscosides, all of which exhibit extremely promising biological activity. The eleutherobins...
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This study examined the microbiota associated with the marine azooxanthellate octocorals Leptogorgia minimata, Swiftia exertia, and Iciligorgia schrammi collected from moderate depths (45 m). Traditional aerobic plate culture, fluorescence in situ hybridization (FISH), and molecular identification o...
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A new dilophol diterpene, eunicidiol (1), has been isolated from the crude extract of Eunicea fusca, a gorgonian coral collected from Hillsboro Ledge, Florida. This compound was purified, along with fuscol (2) and eunicol (3), using a combination of normal- and reversed-phase chromatography methods....
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