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To gather information on the benefits of computer-assisted instruction and other special learning interventions for exceptional children, this study investigated the performance of 12 children (aged 6-12 yrs) with attention deficit hyperactivity disorder (ADHD) on a computerized immediate feedback t...
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Administered one of the beta blockers propranolol (5 or 20 mg/kg) or atenolol (5 or 20 mg/kg) or the alpha-2 agonist clonidine (20 or 100 ?g/kg) in the drinking water to pregnant rats over Gestation Days 1-21. Prenatal exposure to the drugs did not alter the beneficial effects of enriched rearing o...
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Primiparous timed-pregnant Wistar dams were administered a single daily subcutaneous injection of diazepam (1.0 or 5.0 mg/kg) or vehicle over Gestation Days 14-20.
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Schizophrenia is a debilitating neurological disorder characterized by positive, negative, cognitive and/or emotional symptoms. Decreased social interaction is a common negative symptom. Social interaction can be readily observed in rats and is therefore an ideal target behaviour when evaluating an ...
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We have previously reported that serial systemic injections of low-dose (subconvulsive) domoic acid (DOM) during early postnatal development produces changes in both behavior and hippocampal cytoarchitecture in aged rats (17 months) that are similar to those seen in existing animal models of tempora...
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Exposing Sprague–Dawley rat pups to very low, sub-convulsant doses of domoic acid (DOM) during perinatal development has been previously shown to result in seizure-like activity in adulthood similar to partial complex epilepsy in humans, and to produce cellular and molecular changes in the dentate...
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Changes in glutamatergic signalling during neonatal development are known to result in long-lasting changes in brain function. Previous work in our laboratory has shown that systemic administration of very low (subconvulsive) doses of the kainate receptor agonist, domoic acid, during the second post...