The present study examined the effects of neonatal exposure to serial low dose injections of the glutamate agonist, domoic acid (DOM), on learning and memory in two spatial memory tasks in the rat. Neonatal Sprague Dawley rats were given single daily injections of low dose DOM (20 microg/kg) over po...

Prepulse inhibition (PPI) of the acoustic startle response is a measure of sensory motor gating, and is affected in various neuropsychiatric disorders. Although PPI has been used extensively to study both the neural effects of such conditions, as well as in the search for animal models, a number of ...

Activity in the mesocorticolimbic dopamine system is linked to responses to novelty, reward, and drug-seeking behaviours. Glutamate signaling, through kainate receptors, has been shown to modulate dopamine release in this pathway. In the present study, a low, overtly non-convulsive dose of the kaina...