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The interferometric measurement of laser induced thermoelastic expansion of tissue samples can be used to estimate their optical, thermal and mechanical properties. This method was used to assess the Gruneisen coefficient and optical attenuation depth for native and coagulated ex-vivo bovine liver a...
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Laser thermal therapy involves heating tissue using light to temperatures between 55 °C and 95 °C for several minutes resulting in coagulation and cell death. This treatment method has been under investigation for use as a minimally invasive method for treating solid tumors and cancer cells. Heati...
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Optoacoustic imaging is being investigated as a potential tool for monitoring the onset and progression of laser thermal therapy. In this study OA images were acquired from ex vivo bovine liver using a reverse-mode OA imaging system consisting of a pulsed laser operating at 775 nm, and an 8 element ...
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Motivated by a recent report by Dickey et al. [Phys. Med. Biol. 46, 2359 (2001)], who demonstrated optical property retrieval by using relative radiance measurements at a single position, we investigate the uniqueness of relative radiance measurements for quantifying the optical properties of turbid...
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Background and Objectives: Fluoroptic sensors are used to measure interstitial temperatures but their utility for monitoring laser interstitial thermal therapy (LITT) is unclear because these sensors exhibit a measurement artefact when exposed to the near-infrared (NIR) treatment light. This study i...
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Interstitial quantification of the optical properties of tissue is important in biomedicine for both treatment planning of minimally invasive laser therapies and optical spectroscopic characterization of tissues, for example, prostate cancer. In a previous study, we analyzed a method first demonstra...
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Multipoint optical fluence measurements can potentially be used to detect coagulation-induced changes in optical propagation during interstitial laser thermal therapy. Estimating the dimensions of coagulation using on-line optical monitoring, which is applicable to treatments where the tip of the so...
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Background and Objective: Interstitial Laser Photocoagulation (ILP) is a minimally invasive cancer treatment technique, whereby optical energy from implanted optical fibers is used to therapeutically heat small, solid tumors. In this work, the potential of ILP without tissue charring is investigated...
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