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A 2-year old gelding was referred for evaluation of severe right forelimb lameness. The horse was grade 4/5 lame on the right forelimb. Clinical, laboratory, and radiographic findings were consistent with septic arthritis and osteomyelitis. Due to poor prognosis the owner elected euthanasia. Histopa...
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288 mice were divided into four groups and exposed to aerosols of P. haemolytica or S. aureus in four replicates. The numbers of bacteria were determined in the trachea and lungs of mice killed 0, 2, 4, 8, 12, 24, 48 and 72 hours after exposure. Bacterial deposition was greater in lungs than in trac...
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The relationship between acute pulmonary cell injury and inflammatory response was investigated in rats killed 1, 3, and 7 days after tracheal inoculation with bacterial lipopolysaccharide (LPS). Inoculation with LPS induced an influx of polymorphonuclear leukocytes (PMN) and a mild increase in pulm...
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One of the major target organs of hydrogen sulphide gas is the lung. Exfoliation of upper respiratory epithelia and pulmonary edema are prominent effects. Various neuropeptides contained in afferent C-fibres are intimately associated with the epithelia of the conducting airways and are liberated upo...
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Three, 5 or 7 days after inoculation with bovine viral diarrhea (BVD) virus (n = 12) or Mycoplasma bovis (n = 12), groups of calves were exposed to aerosols of Pasteurella haemolytica and were euthanatized 44 hours later. Histologic lesions in the lungs and the ratios of neutrophils to alveolar macr...
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A dog adopted as a stray in Spain and then brought to Canada 4 years prior to presentation was evaluated for polyarthritis. An electrophoresis showed a marked polyclonal gammopathy and synovial smears contained leishmanial organisms within macrophages.
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The meconium aspiration syndrome is an important cause of respiratory distress in newborn infants. Alveolar macrophages (AMs) provide a first line of defense in the lower respiratory tract against inhaled pathogens and particles such as meconium. In this study, we examined the effect of meconium on ...
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A 3 1/2 -month-old pub with oculonasal discharge and seizures was submitted for postmortem examination. Grossly, the lungs had cranioventral consolidation, and microscopically, 2 distinct types of inclusion bodies compatible with Canine distemper virus and Canine adenovirus type 2. Presence of both ...
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Background and Purpose: Studying the effects of toxic and infective compounds on the respiratory system requires a reliable method for delivering inoculum into the distal region of the lung. Although transoral intratracheal inoculation methods have been well documented for adult rats, to the authors...
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38 Wistar rats with a mean weight of 177 g were divided in 5 groups. Rats were inoculated i.t. with 0.5 ml of fluid (made up to a constant volume using saline solution) containing 2.5 mg of silica, but a variable amount of amniotic fluid (0, 0.125, 0.250, 0.375 or 0.500 ml). The rats were killed 72 ...
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A Clydesdale mare was examined for weight loss, inappetence, ptyalism, and dysphagia. The main abnormality revealed by serum biochemistry was a marked hyperglobulinemia, and protein electrophoresis revealed a monoclonal gammopathy in the gamma region. The urine was positive for Bence Jones proteins....
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Meconium staining of the skin is a common event associated with fetal hypoxia, stillbirths, weak-born piglets, and neonatal mortality. Aspiration of meconium leads to meconium aspiration syndrome (MAS). This study was undertaken to assess the relationship between the degree of meconium staining of t...
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The aim of this investigation was to do a comparative study on the deposition and clearance of inhaled bacteria between the lungs and tracheae of mice exposed to aerosols of bacteria. Mice were divided into 4 groups of 72 each and exposed to aerosols of P. haemolytica or S. aureus in 4 replicates. T...
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The ability of infectious bursal disease virus (IBDV) serotypes 1 and 2, and the role of VP4 of both serotypes as well as the capacity of three IBDV intermediate serotype 1-specific vaccine strains to induce apoptosis in a chicken B-lymphocyte cell line, DT40, were investigated using the TUNEL techn...
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