The pH stability and acute oral toxicity of dimethoxymethane (DMM) in rats were studied, In in vitro studies, DMM was found to be stable in artificial gastric juice at pH 2.5 and above but readily hydrolyzed at pH2 and below, with 1 mole of DMM producing approximately 1 mole of formaldehyde and 2 mo...

The purpose of this study was to establish the effects of lead on the non-human primate testis. Sixteen cynomolgus monkeys maintained in environmentally controlled conditions were administered 1500 mug lead acetate/kg bw/day in gelatin capsules. Monkeys were randomly assigned to the following groups...

Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants that bioaccumulate in the food chain and thus pose a health risk to humans and other animals. In this study, PCB 118 was added to the diets of Sprague Dawley rats for 13 weeks in concentrations of 2, 20, 200, 2000 p.p.b. to t...

Hexachlorobenzene is a persistent chlorinated organic chemical that has been detected in many tissues from a variety of species including human ovary and human ovarian follicular fluid. When administered in high dosage to nonhuman primates, hexachlorobenzene causes destruction of ovarian primordial ...

Although reproductive consequences of high circulating blood lead levels (greater than or equal to 60 mu g/dL) have been reported, potential adverse effects of chronic lead exposure in males that result in low to moderate blood lead levels (10-25 and 26-60 mu g/dL, respectively) are unknown. Effects...

Effect of Tower rapeseed oil (RO) containing lower (0.4%) erucic acid on the piglet liver was studied by electron microscopy. The animals were placed in two groups of four and were fed the diets for eight weeks. Animals in the treated group were given a basal diet comprising corn-soybean plus Tower ...

Polyhalogenated aromatic compounds such as polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins continue to be environmental contaminants because of their bioaccumulation in the food chain and resistance to biodegradation. This study was undertaken to determine if WHO-IPCS PCB cong...