Pilot study demonstrating that immunostimulation ...
|Title||Pilot study demonstrating that immunostimulation with β glucan fails to moderate the immunosuppressive effects of dexamethasone when co-administered to rainbow trout Oncorhynchus mykiss experimentally challenged with the microsporidian Loma salmonae|
|Author(s)||D. J. Speare, N. J. Guselle, J. E. Harkness|
|Journal||Gyobyo Kenkyu = Fish Pathology|
|Abstract||In this pilot study, juvenile rainbow trout were experimentally challenged with the microsporidian Loma salmonae to determine the effects of immunostimulation with β-1,3/1,6 glucan administered in the feed at 200 mg/kg of feed, and immunosuppression with dexamethasone at 300 mg/kg of feed when these were administered in the early stages of infection. Six weeks after oral exposure to Loma spores, control fish developed a mean of 34.8 spore filled xenomas per gill arch; those which had received β glucan had significantly fewer xenomas (23.6) whereas those receiving dexamethasone had significantly more (43.0). Paradoxically, when fish received both β glucan and dexamethasone in any of three temporal combinations, xenoma numbers were significantly higher (51.0-65.1) even when compared to fish receiving only dexamethasone.|
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