Synthesis of hydroxyquinoline derivatives, ...
|Title||Synthesis of hydroxyquinoline derivatives, aminohydroxychromene, aminocoumarin and their antibacterial activities.|
|Author(s)||A. Abd-El-Aziz, A. El-Agrody, A. Bedair, T. Corkery, A. Ata|
|Journal||Section Title: Heterocyclic Compounds (One Hetero Atom), Heterocycles|
|Abstract||Some diaminochromenes, e.g., I, 7-amino-4-aryl-coumarins, 7-hydroxy-4-aryl-1,2-dihydroquinolines, and 2-amino-7-hydroxy-4-(4-chlorophenyl)-4H-chromenes were synthesized via Michael addn. of different substituted aminonaphthol, aminophenol, resorcinol derivs., chloronaphthol, and 4-hydroxycoumarin with Î±-cyanocinnamonitriles and Et Î±-cyanocinnamates. 2-Acetylamino-7-amino-4-(4-chlorophenyl)-4H-chromene-2-carbonitrile was obtained as a unique product via hydrazinolysis of the corresponding ethoxymethyleneamino deriv. The formation of coumarins and quinolines were anomalous case. Structures of the titled compds. were elucidated by spectrometric data; IR, 1H NMR, 13C NMR (APT), and EMS. All of the synthesized compds. were evaluated for antimicrobial activities, and some of the compds. exhibited activity against staphylococcus aureus (ATCC 25923). [on SciFinder(R)]|
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