Short-term infection of striped bass Morone saxatilis with Mycobacterium marinum

Short-term infection of striped bass Morone ...

Title	Short-term infection of striped bass Morone saxatilis with Mycobacterium marinum
Author(s)	S. Jeon, L. Gonsalves, J. Jacobs, M. Rhodes, J. Councilman, A. Baya, E. May, M. Fast
Journal	Diseases of Aquatic Organisms
Date	2011
Volume	94
Issue	2
Start page	117
End page	124
Abstract	Striped bass Morone saxatilis were studied in order to characterize their immune responses over the short term following challenge with Mycobacterium marinum. The expression of immunity-related genes (IL-1beta, TNF-alpha, Nramp and TGF-beta) quickly increased following infection with M. marinum, but these genes were subsequently down-regulated despite the fact that bacterial counts remained high. The number of monocytes and neutrophils also initially increased at 1 d postinfection. This confirms the importance of these types of cells in initial inflammation and mycobacterial infection in striped bass. The phagocytic index of splenic leukocytes over these same time frames did not change significantly following infection. The discrete window in which inflammatory mechanisms were stimulated in striped bass may be related to the intracellular nature of this pathogen.
ISSN	0177-5103

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