Aquareovirus effects syncytiogenesis by using a ...
|Title||Aquareovirus effects syncytiogenesis by using a novel member of the FAST protein family translated from a noncanonical translation start site|
|Author(s)||Trina Racine, Tara Hurst, Chris Barry, Jingyun Shou, Frederick Kibenge, Roy Duncan|
|Journal||Journal of Virology|
|Abstract||As nonenveloped viruses, the aquareoviruses and orthoreoviruses are unusual in their ability to induce cell-cell fusion and syncytium formation. While an extraordinary family of fusion-associated small transmembrane (FAST) proteins is responsible for orthoreovirus syncytiogenesis, the basis for aquareovirus-induced syncytiogenesis is unknown. We now report that the S7 genome segment of an Atlantic salmon reovirus is polycistronic and uses a noncanonical CUG translation start codon to produce a 22-kDa integral membrane protein responsible for syncytiogenesis. The aquareovirus p22 protein represents a fourth distinct member of the FAST family with a unique repertoire and arrangement of structural motifs.|
Using APA 6th Edition citation style.
Times viewed: 329