Experimental reproduction of severe bluetongue in sheep

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Title Experimental reproduction of severe bluetongue in sheep
Author(s) N. J. MacLachlan, J. E. Crafford, W. Vernau, I. A. Gardner, A. Goddard, A. J. Guthrie, E. H. Venter
Journal Veterinary Pathology
Date 2008
Volume 45
Issue 3
Start page 310
End page 315
Abstract Sheep inoculated with a virulent South African strain of bluetongue (BT) virus serotype 4 developed severe clinical signs and lesions characteristic of fulminant BT, including coronitis, hemorrhage and ulceration of the mucosal lining of the oral cavity and forestomaches, hemorrhage in the wall of the pulmonary artery, and focally extensive necrosis of skeletal muscle, especially of the neck. At necropsy, up to 14 days after infection, the infected sheep exhibited striking pulmonary edema, edema of the subcutaneous tissues and fascial planes of the head and neck, and pleural and pericardial effusion of varying severity. A reliable model for experimental reproduction of fulminant BT in sheep will facilitate future studies to better characterize the pathogenesis of this disease, particularly as it regards the mechanisms responsible for the increased vascular permeability that characterizes BT and related orbiviral diseases such as African horse sickness.
DOI 10.1354/vp.45-3-310

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