Production of shiga toxin by a luxS mutant of ...

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Title Production of shiga toxin by a luxS mutant of Escherichia coli O157: H7 in vivo and in vitro
Author(s) Byeonghwa Jeon, Kikuji Itoh
Journal Microbiology and Immunology
Date 2007
Volume 51
Issue 4
Start page 391
End page 396
Abstract Quorum sensing is a type of bacterial communication mediated by chemical signaling molecules called autoinducers (AIs). The production of AI-2 and AI-3 is dependent on the luxS gene in Escherichia coli O157:H7. A luxS mutation caused a minimal decrease (about 2-fold) in Shiga toxin (Stx) production in in vitro cultures using Luria-Bertani broth. The effect of a luxS mutation on the virulence of E. coli O157:H7 was examined by using germfree mice. There were no differences between the luxS mutant and the wild-type in the bacterial counts in feces shedding, Stx production, or the survival of the mice. The treatment of ciprofloxacin decreased the bacteria in feces but increased the Stx production. However, even treatment with ciprofloxacin did not make any difference between the luxS mutant and the wild-type in animal experiments.

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