Period-doubling instability and memory in cardiac tissue
|Title||Period-doubling instability and memory in cardiac tissue|
|Author(s)||Jeffrey J. Fox, Eberhard Bodenschatz, Robert F.,,Jr Gilmour|
|Journal||Physical Review Letters|
|Abstract||Theoretical studies have indicated that alternans (period-doubling instability) of action potential duration is associated with a restitution relation with a slope >or=1. However, recent experimental findings suggest that the slope of the restitution relation is not necessarily predictive of alternans. Here, we compared a return map memory model to action potential data from an ionic model and found that the memory model reproduced dynamics that could not be explained by a unidimensional restitution relation. Using linear stability analysis, we determined the onset of the alternans in the memory model and confirmed that the slope of the restitution curve was not predictive.|
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