The impact of smoking and polymorphic enzymes of ...
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| Title | The impact of smoking and polymorphic enzymes of xenobiotic metabolism on the stage of bladder tumors: a generalized ordered logistic regression analysis |
| Author(s) | S. Khedhiri, N. Stambouli, S. Ouerhani, K. Rouissi, R. Marrakchi, A. Gaaied, M. Slama |
| Journal | Journal of Cancer Research and Clinical Oncology |
| Date | 2010 |
| Volume | 136 |
| Issue | 7 |
| Start page | 1111 |
| End page | 1116 |
| Abstract | Cigarette smoking is the predominant risk factor for bladder cancer in males and females. The tobacco carcinogens are metabolized by various xenobiotic metabolizing enzymes such as N-acetyltransferases (NAT) and glutathione S-transferases (GST). Polymorphisms in NAT and GST genes alter the ability of these enzymes to metabolize carcinogens. In this paper, we conduct a statistical analysis based on logistic regressions to assess the impact of smoking and metabolizing enzyme genotypes on the risk to develop bladder cancer using a case-control study from Tunisia. We also use the generalized ordered logistic model to investigate whether these factors do have an impact on the progression of bladder tumors. |
| DOI | 10.1007/s00432-009-0758-2 |
| ISSN | 1432-1335,0171-5216 |
Using APA 6th Edition citation style.
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