Lidocaine converts acute vagally associated atrial ...



Title Lidocaine converts acute vagally associated atrial fibrillation to sinus rhythm in German Shepherd dogs with inherited arrhythmias
Author(s) R. Pariaut, N.S. Moïse, B. D. Koetje, J. A. Flanders, S. A. Hemsley, T. B. Farver, R. F., J. Gilmour, A. R. M. Gelzer, M. S. Kraus, N. F. Otani
Journal Journal of Veterinary Internal Medicine / American College of Veterinary Internal Medicine
Date 2008
Volume 22
Issue 6
Start page 1274
End page 1282
Abstract Background: Hypothesis: Animals: Methods: Results: Conclusions and Clinical Importance: Lidocaine is most frequently used to treat ventricular arrhythmias. However, lidocaine may have an antiarrhythmic effect for certain supraventricular arrhythmias.We hypothesized that lidocaine would be effective in converting experimentally induced atrial fibrillation (AF) to sinus rhythm and that a decrease in the dominant frequency (DF) and an increase in the organization as judged by the spectral entropy (SE) would occur over the course of the conversion.Seven German Shepherd (GS) Dogs.Dogs were anesthetized with fentanyl and pentobarbital. AF was induced with standard pacing protocols while left and right atrial monophasic action potentials (MAP) were recorded. The power spectra from the MAP recordings were analyzed to determine DF and SE during treatment with boluses of 2 mg/kg lidocaine.Lidocaine converted AF to sinus rhythm in all dogs and all episodes (n = 19). Conversion time was 27-87 seconds. After atropine, sustained AF was not induced; however, 5 episodes of atrial tachycardia resulted, and 3 were converted with lidocaine. Frequency domain analysis of 12 conversion sequences showed that left and right DF of the MAP signals decreased from the time of injection to conversion to sinus rhythm (P < .001). Mean SE indicated a gradient between the left and right atria (P = .003) that did not change during conversion.Vagally associated AF in GS dogs is terminated with lidocaine. Lidocaine is likely an effective treatment in clinical dogs with vagally associated AF.
DOI 10.1111/j.1939-1676.2008.0188.x

Using APA 6th Edition citation style.

[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]

Times viewed: 425

Adding this citation to "My List" will allow you to export this citation in other styles.