Strategy for control of complex low-dimensional ...

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Title Strategy for control of complex low-dimensional dynamics in cardiac tissue
Author(s) M. Watanabe, R. F., J. Gilmour
Journal Journal of Mathematical Biology
Date 1996
Volume 35
Issue 1
Start page 73
End page 87
Abstract Heart rate-dependent alterations in the duration of the electrically active state of cardiac cells, the action potential, are an important determinant of lethal heart rhythm disorders. The relationship between action potential duration and heart rate can be modelled as a nonlinear one-dimensional map. Iteration of the map over a range of physiologically relevant heart rates produces complex changes in action potential duration, including period doubling bifurcations, chaos and period doubling reversals. We present a computer algorithm that ensures, over the same range of heart rates, uniform state variable values (action potential durations) by application of small perturbing stimuli at appropriate intervals. The algorithm succeeds, even though the only parameter in the system (the heart rate) is immutable. Control of the dynamics is achieved by exploiting the inexcitability of the cardiac cells immediately after stimulation. This algorithm may have applications for the prevention of cardiac rhythm disturbances.
DOI 10.1007/s002850050043

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