New animal models of progressive neurodegeneration



Title New animal models of progressive neurodegeneration: tools for identifying targets in predictive diagnostics and presymptomatic treatment
Author(s) R. Andrew Tasker, Amber L. Adams-Marriott, Christopher A. Shaw
Journal EPMA Journal
Date 2010
Volume 1
Issue 2
Start page 217
End page 227
Abstract Mental and neurological disorders are increasingly prevalent and constitute a major societal and economic burden worldwide. Many of these diseases and disorders are characterized by progressive deterioration over time, that ultimately results in identifiable symptoms that in turn dictate therapy. Disease-specific symptoms, however, often occur late in the degenerative process. A better understanding of presymptomatic events could allow for the development of new diagnostics and earlier interventions that could slow or stop the disease process. Such studies of progressive neurodegeneration require the use of animal models that are characterized by delayed or slowly developing disease phenotype(s). This brief review describes several examples of such animal models that have recently been developed with relevance to various neurological diseases and disorders, and delineates the potential of such models to aid in predictive diagnosis, early intervention and disease prevention.
DOI 10.1007/s13167-010-0019-0
Use/Reproduction CC-BY

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