Differential neuroprotection of selective estrogen ...
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Citation
| Title | Differential neuroprotection of selective estrogen receptor agonists against autonomic dysfunction and ischemic cell death in permanent versus reperfusion injury |
| Author(s) | B. Connell, T. Saleh |
| Journal | Advances in Pharmacological Sciences |
| Date | 2011 |
| Volume | 2011 |
| Issue | |
| Start page | 976951 |
| Abstract | In the present study, we tested the hypothesis that selective activation of estrogen receptor subtypes (ERalpha and ERbeta) would be neuroprotective following ischemia and/or ischemia-reperfusion, as well as prevent the associated autonomic dysfunction. The selective ERalpha agonist, PPT, when administered 30 min prior to occlusion of the middle cerebral artery (pMCAO), resulted in a dose-dependent neuroprotection as measured 6 hours postpermanent MCAO, but not following 30 mins of MCAO followed by 5.5 hrs of reperfusion (I/R). In contrast, 30 min pretreatment with the selective ERbeta agonist, DPN, resulted in a dose-dependent neuroprotection following I/R, but was not protective following pMCAO. Both drugs prevented the ischemia-induced autonomic dysfunction as measured by a decrease in the baroreceptor reflex sensitivity (BRS). The data presented here suggest a differential role of each ER subtype in targeting the mechanisms of cell death that occur in ischemia versus reperfusion injury. |
| DOI | 10.1155/2011/976951 |
| Use/Reproduction | Contact Publisher |
| Text | http://www.islandscholar.ca/scholartest/download_ds/ir:954/PDF |
Using APA 6th Edition citation style.
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