Alastair Cribb

Description

Details

NameAlastair Cribb
PositionFaculty Member
Emailacribb@upei.ca
Department(s)Biomedical Sciences
Websitehttp://www.upei.ca/~anatphys/cribb/cribbBIO.htm

Alastair Cribb

Biography

Dr. Cribb completed his PhD in Clinical Pharmacology at the Hospital for Sick Children, University of Toronto in 1991, after completing his DVM degree at the University of Saskatchewan in 1984. During his PhD, he studied genetic susceptibility to adverse drug reactions. He completed a post-doctoral fellowship in the Faculty of Medicine at Dalhousie University, where he investigated the regulation of cytochrome P450 enzymes during inflammation. He then spent four years in human drug development with Merck & Co, USA where he continued to assess the genetic basis for variable drug response. He joined AVC and UPEI in 1996. He accepted the position of Dean, Faculty of Veterinary Medicine, University of Calgary, in May, 2006.


Recent Citations


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Research Interests

  • Molecular mechanisms of drug and chemical toxicity in animals and humans
  • The pharmacogenetic basis of adverse drug reactions and cancer susceptibility

Other Scholars in Biomedical Sciences

Citations

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TitleAuthor(s)
Eosinophilic meningoencephalitis in a catSchultze, A. E.; Cribb, Alastair E.; Tvedten, H. W.
Disruption of the endoplasmic reticulum by cytotoxins in LLC-PK1 cellsRyan, P. M.; Bedard, K.; Breining, T.; Cribb, Alastair E.
Modulation of rat hepatic CYP3A1 induction by the interferon inducer polyinosinic acid-polycytidylic acid (polyic)Delaporte, E.; Cribb, Alastair E.; Renton, K. W.
Interferon-mediated changes in the expression of CYP1A1 in human B lymphoblastoid (AHH-1 TK +/-) cellsDelaporte, E.; Cribb, Alastair E.; Renton, K. W.
Laryngeal paralysis in a mature cat. [Correspondence]Cribb, Alastair E.
Assessment of arylamine N-acetyltransferase (NAT1) activity in mononuclear leukocytes of cystic fibrosis patientsCribb, Alastair E.; Tsui, B.; Isbrucker, R.; Michael, R. T.; Gillespie, C. T.; Brown-Bonomo, J.; Barrett, P.; Levatte, T.; Renton, K. W.
Sulfamethoxazole is metabolized to the hydroxylamine in humansCribb, Alastair E.; Spielberg, S. P.
Peroxidase-dependent oxidation of sulfonamides by monocytes and neutrophils from humans and dogsCribb, Alastair E.; Miller, M.; Tesoro, A.; Spielberg, S. P.
Further investigations of the role of acetylation in sulphonamide hypersensitivity reactionsNuss, C. E.; Grant, D. M.; Spielberg, S. P.; Cribb, Alastair E.
Use of a microplate reader in an assay of glutathione reductase using 5,5'-dithiobis(2-nitrobenzoic acid)Cribb, Alastair E.; Leeder, J. S.; Spielberg, S. P.
The endoplasmic reticulum in xenobiotic toxicityCribb, Alastair E.; Peyrou, M.; Muruganandan, S.; Schneider, L.
Hepatic microsomal metabolism of sulfamethoxazole to the hydroxylamineCribb, Alastair E.; Spielberg, S. P.
In vitro formation, disposition and toxicity of N-acetoxy-sulfamethoxazole, a potential mediator of sulfamethoxazole toxicityNakamura, H.; Uetrecht, J.; Cribb, Alastair E.; Miller, M. A.; Zahid, N.; Hill, J.; Josephy, P. D.; Grant, D. M.; Spielberg, S. P.
Reactions of the nitroso and hydroxylamine metabolites of sulfamethoxazole with reduced glutathione. Implications for idiosyncratic toxicityCribb, Alastair E.; Miller, M.; Leeder, J. S.; Hill, J.; Spielberg, S. P.
Sulfonamides and keratoconjunctivitis sicca: replyCribb, Alastair E.
Mild endoplasmic reticulum stress provides cytoprotection against nephrotoxic drugs in LLC-PK1 cellsPeyrou, M.; Cribb, Alastair E.
Idiosyncratic reactions to sulfonamides in dogsCribb, Alastair E.
An in vitro investigation of predisposition to sulphonamide idiosyncratic toxicity in dogsCribb, Alastair E.; Spielberg, S. P.
Effect of lipopolysaccharide (LPS)-evoked host defense activation on hepatic microsomal formation and reduction of sulfamethoxazole hydroxylamine in the ratCribb, Alastair E.; McQuaid, T.; Renton, K. W.
Bile-duct obstruction secondary to chronic-pancreatitis in 7 dogsCribb, Alastair E.; Burgener, D. C.; Reimann, K. A.
The duration of induction and species influences the downregulation of cytochrome P450 by the interferon inducer polyinosinic acid-polycytidylic acidAnari, M. R.; Cribb, Alastair E.; Renton, K. W.
Patients with delayed-onset sulfonamide hypersensitivity reactions have antibodies recognizing endoplasmic reticulum luminal proteins (vol 282, pg 1064, 1997)Cribb, Alastair E.; Pohl, L. R.; Spielberg, S. P.; Leeder, J. S.
Giardiasis in a homeCribb, Alastair E.; Spracklin, D.
Acetylator phenotypingCribb, Alastair E.; Isbrucker, R.; Levatte, T.; Tsui, B.; Gillespie, C. T.; Renton, K. W.
Pancreatitis associated with potassium bromide/phenobarbital combination therapy in epileptic dogsGaskill, C. L.; Cribb, Alastair E.
Glutathione transferase mu deficiency is not a marker for predisposition to sulphonamide toxicityRiley, R. J.; Cribb, Alastair E.; Spielberg, S. P.
Cytosolic arylamine N-acetyltransferase (NAT) deficiency in the dog and other canids due to an absence of NAT genesTrepanier, L. A.; Ray, K.; Winand, N. J.; Spielberg, S. P.; Cribb, Alastair E.
Urethral pressure profile and hemodynamic effects of phenoxybenzamine and prazosin in non-sedated male beagle dogsFischer, J. R.; Lane, I. F.; Cribb, Alastair E.
N4-hydroxylation of sulfamethoxazole by cytochrome P450 of the cytochrome P4502C subfamily and reduction of sulfamethoxazole hydroxylamine in human and rat hepatic microsomesCribb, Alastair E.; Spielberg, S. P.; Griffin, G. P.
Increased cosedimentation of cytosolic glutathione S-transferases with microsomal fractions prepared from frozen rat liverCribb, Alastair E.; Griffin, G. P.; Spielberg, S. P.; Rushmore, T. H.; Chauret, N.; Nicoll-Griffith, D. A.
Formation and disposition of sulfamethoxazole hydroxylamine (SMX-HA)Spielberg, S. P.; Nuss, C. E.; Cribb, Alastair E.
Novel non-labile covalent binding of sulfamethoxazole reactive metabolites to cultured human lymphoid cellsSumman, M.; Cribb, Alastair E.
Drug-induced hypothyroidismGupta, A.; Eggo, M. C.; Uetrecht, J. P.; Cribb, Alastair E.; Daneman, D.; Rieder, M. J.; Shear, N. H.; Cannon, M.; Spielberg, S. P.
Adverse reactions to sulphonamide and sulphonamide-trimethoprim antimicrobialsCribb, Alastair E.; Lee, B. L.; Trepanier, L. A.; Spielberg, S. P.
Role of altered drug metabolism in virus-drug interactionsRenton, K. W.; Cribb, Alastair E.; Armstrong, S.
Calpain-induced endoplasmic reticulum stress and cell death following cytotoxic damage to renal cellsMuruganandan, S.; Cribb, Alastair E.
Patients with delayed-onset sulfonamide hypersensitivity reactions have antibodies recognizing endoplasmic reticulum luminal proteinsCribb, Alastair E.; Pohl, L. R.; Spielberg, S. P.; Leeder, J. S.
InterferonsCribb, Alastair E.; Renton, K. W.; Armstrong, S. G.
Covalent binding of sulfamethoxazole reactive metabolites to human and rat liver subcellular fractions assessed by immunochemical detectionCribb, Alastair E.; Nuss, C. E.; Alberts, D. W.; Lamphere, D. B.; Grant, D. M.; Grossman, S. J.; Spielberg, S. P.
Regulation of cytochrome P-4501A and cytochrome P-4502E induction in the rat during the production of interferon alpha/betaCribb, Alastair E.; Delaporte, E.; Kim, S. G.; Novak, R. F.; Renton, K. W.
(+)-bufuralol 1'-hydroxylation activity in human and rhesus monkey intestine and liverPrueksaritanont, T.; Dwyer, L. M.; Cribb, Alastair E.
Role of polymorphic and monomorphic human arylamine N-acetyltransferases in determining sulfamethoxazole metabolismCribb, Alastair E.; Nakamura, H.; Grant, D. M.; Miller, M. A.; Spielberg, S. P.
Effects of season and sample handling on measurement of plasma alpha-melanocyte-stimulating hormone concentrations in horses and poniesMcFarlane, D.; Donaldson, M. T.; McDonnell, S. M.; Cribb, Alastair E.
In-vitro formation, disposition and toxicity of n-acetoxy-sulffamethoxazole, a potential mediator of sulfamethoxazole toxicityNakamura, H.; Uetrecht, J.; Cribb, Alastair E.; Miller, M. A.; Zahid, N.; Hill, J.; Josephy, P. D.; Grant, D. M.; Spielberg, S. P.
Feline gastrointestinal adenocarcinomaCribb, Alastair E.
Antigenicity and immunogenicity of sulphamethoxazoleNaisbitt, D. J.; Gordon, S. F.; Pirmohamed, M.; Burkhart, C.; Cribb, Alastair E.; Pichler, W. J.; Park, B. K.
Deficiency of cytosolic arylamine N-acetylation in the domestic cat and wild felids caused by the presence of a single NAT1-like geneTrepanier, L. A.; Cribb, Alastair E.; Spielberg, S. P.; Ray, K.
Dissociation of xanthine oxidase induction and cytochrome P450 depression during interferon induction in the ratCribb, Alastair E.; Renton, K. W.
Expression of monomorphic arylamine N-acetyltransferase (NAT1) in human leukocytesCribb, Alastair E.; Grant, D. M.; Miller, M. A.; Spielberg, S. P.
Systemic and pituitary pars intermedia antioxidant capacity associated with pars intermedia oxidative stress and dysfunction in horsesMcFarlane, D.; Cribb, Alastair E.
Bile duct obstruction secondary to chronic pancreatitis in seven dogsCribb, Alastair E.; Burgener, D. C.; Reimann, K. A.
Serum alkaline phosphatase isoenzyme profiles in phenobarbital-treated epileptic dogsGaskill, C. L.; Hoffmann, W. E.; Cribb, Alastair E.
The Long Evans Cinnamon (LEC) rat develops hepatocellular damage in the absence of antimicrosomal antibodiesBedard, K.; Fuentealba, I. C.; Cribb, A.
Hepatotoxic effects associated to short and long term exposure to excess dietary copper in ratsAburto, E.; Cribb, A.; Fuentealba, C.

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TitleTimes viewedLast viewed
Eosinophilic meningoencephalitis in a cat - ir:ir-batch6-84229910:54:29 2014-08-19
Disruption of the endoplasmic reticulum by cytotoxins in LLC-PK1 cells - ir:ir-batch6-79723419:11:49 2014-08-12
Modulation of rat hepatic CYP3A1 induction by the interferon inducer polyinosinic acid-polycytidylic acid (polyic) - ir:ir-batch6-82221221:32:22 2014-08-20
Interferon-mediated changes in the expression of CYP1A1 in human B lymphoblastoid (AHH-1 TK +/-) cells - ir:ir-batch6-81220614:59:18 2014-08-15
Laryngeal paralysis in a mature cat. [Correspondence] - ir:ir-batch6-84122518:29:01 2014-08-11
Assessment of arylamine N-acetyltransferase (NAT1) activity in mononuclear leukocytes of cystic fibrosis patients - ir:ir-batch6-81723122:06:25 2014-08-16
Sulfamethoxazole is metabolized to the hydroxylamine in humans - ir:ir-batch6-82424111:54:22 2014-08-20
Peroxidase-dependent oxidation of sulfonamides by monocytes and neutrophils from humans and dogs - ir:ir-batch6-83119503:55:07 2014-08-05
Further investigations of the role of acetylation in sulphonamide hypersensitivity reactions - ir:ir-batch6-78720102:16:45 2014-08-10
Use of a microplate reader in an assay of glutathione reductase using 5,5'-dithiobis(2-nitrobenzoic acid) - ir:ir-batch6-83523522:46:13 2014-08-17
The endoplasmic reticulum in xenobiotic toxicity - ir:ir-batch6-79629215:18:37 2014-08-11
Hepatic microsomal metabolism of sulfamethoxazole to the hydroxylamine - ir:ir-batch6-83220211:57:48 2014-08-19
In vitro formation, disposition and toxicity of N-acetoxy-sulfamethoxazole, a potential mediator of sulfamethoxazole toxicity - ir:ir-batch6-81422716:19:30 2014-08-18
Reactions of the nitroso and hydroxylamine metabolites of sulfamethoxazole with reduced glutathione. Implications for idiosyncratic toxicity - ir:ir-batch6-82919623:11:08 2014-08-16
Sulfonamides and keratoconjunctivitis sicca: reply - ir:ir-batch6-79020314:52:51 2014-08-15
Mild endoplasmic reticulum stress provides cytoprotection against nephrotoxic drugs in LLC-PK1 cells - ir:ir-batch6-78532208:33:50 2014-08-20
Idiosyncratic reactions to sulfonamides in dogs - ir:ir-batch6-83420620:54:02 2014-08-12
An in vitro investigation of predisposition to sulphonamide idiosyncratic toxicity in dogs - ir:ir-batch6-83317922:44:49 2014-08-18
Effect of lipopolysaccharide (LPS)-evoked host defense activation on hepatic microsomal formation and reduction of sulfamethoxazole hydroxylamine in the rat - ir:ir-batch6-80422516:09:14 2014-08-14
Bile-duct obstruction secondary to chronic-pancreatitis in 7 dogs - ir:ir-batch6-79118014:51:57 2014-08-20
The duration of induction and species influences the downregulation of cytochrome P450 by the interferon inducer polyinosinic acid-polycytidylic acid - ir:ir-batch6-81520305:03:51 2014-08-18
Patients with delayed-onset sulfonamide hypersensitivity reactions have antibodies recognizing endoplasmic reticulum luminal proteins (vol 282, pg 1064, 1997) - ir:ir-batch6-78621111:46:49 2014-08-20
Giardiasis in a home - ir:ir-batch6-79217913:54:01 2014-08-20
Acetylator phenotyping - ir:ir-batch6-81918202:55:18 2014-08-12
Pancreatitis associated with potassium bromide/phenobarbital combination therapy in epileptic dogs - ir:ir-batch6-39719609:01:14 2014-08-18
Glutathione transferase mu deficiency is not a marker for predisposition to sulphonamide toxicity - ir:ir-batch6-83020905:57:50 2014-08-20
Cytosolic arylamine N-acetyltransferase (NAT) deficiency in the dog and other canids due to an absence of NAT genes - ir:ir-batch6-80919913:05:52 2014-07-31
Urethral pressure profile and hemodynamic effects of phenoxybenzamine and prazosin in non-sedated male beagle dogs - ir:ir-batch6-80120118:23:08 2014-08-20
N4-hydroxylation of sulfamethoxazole by cytochrome P450 of the cytochrome P4502C subfamily and reduction of sulfamethoxazole hydroxylamine in human and rat hepatic microsomes - ir:ir-batch6-81620003:50:10 2014-08-20
Increased cosedimentation of cytosolic glutathione S-transferases with microsomal fractions prepared from frozen rat liver - ir:ir-batch6-81823003:46:35 2014-08-16
Formation and disposition of sulfamethoxazole hydroxylamine (SMX-HA) - ir:ir-batch6-78919815:22:10 2014-08-19
Novel non-labile covalent binding of sulfamethoxazole reactive metabolites to cultured human lymphoid cells - ir:ir-batch6-80221910:19:17 2014-08-20
Drug-induced hypothyroidism - ir:ir-batch6-82617216:06:27 2014-08-20
Adverse reactions to sulphonamide and sulphonamide-trimethoprim antimicrobials - ir:ir-batch6-81020707:37:58 2014-08-15
Role of altered drug metabolism in virus-drug interactions - ir:ir-batch6-82823415:49:00 2014-08-13
Calpain-induced endoplasmic reticulum stress and cell death following cytotoxic damage to renal cells - ir:ir-batch6-79326206:47:59 2014-08-20
Patients with delayed-onset sulfonamide hypersensitivity reactions have antibodies recognizing endoplasmic reticulum luminal proteins - ir:ir-batch6-80821907:44:36 2014-08-20
Interferons - ir:ir-batch6-82517720:41:47 2014-08-15
Covalent binding of sulfamethoxazole reactive metabolites to human and rat liver subcellular fractions assessed by immunochemical detection - ir:ir-batch6-81122012:35:53 2014-08-01
Regulation of cytochrome P-4501A and cytochrome P-4502E induction in the rat during the production of interferon alpha/beta - ir:ir-batch6-82017703:32:03 2014-08-20
(+)-bufuralol 1'-hydroxylation activity in human and rhesus monkey intestine and liver - ir:ir-batch6-81323514:39:02 2014-08-19
Role of polymorphic and monomorphic human arylamine N-acetyltransferases in determining sulfamethoxazole metabolism - ir:ir-batch6-82320819:19:24 2014-07-31
Effects of season and sample handling on measurement of plasma alpha-melanocyte-stimulating hormone concentrations in horses and ponies - ir:ir-batch6-79921104:19:39 2014-08-11
In-vitro formation, disposition and toxicity of n-acetoxy-sulffamethoxazole, a potential mediator of sulfamethoxazole toxicity - ir:ir-batch6-78821302:37:53 2014-08-20
Feline gastrointestinal adenocarcinoma - ir:ir-batch6-84021422:11:31 2014-08-20
Antigenicity and immunogenicity of sulphamethoxazole - ir:ir-batch6-80521419:32:04 2014-08-20
Deficiency of cytosolic arylamine N-acetylation in the domestic cat and wild felids caused by the presence of a single NAT1-like gene - ir:ir-batch6-80719711:00:10 2014-08-18
Dissociation of xanthine oxidase induction and cytochrome P450 depression during interferon induction in the rat - ir:ir-batch6-82121805:09:53 2014-08-16
Expression of monomorphic arylamine N-acetyltransferase (NAT1) in human leukocytes - ir:ir-batch6-82720718:34:18 2014-08-20
Systemic and pituitary pars intermedia antioxidant capacity associated with pars intermedia oxidative stress and dysfunction in horses - ir:ir-batch6-79425816:50:06 2014-08-19
Bile duct obstruction secondary to chronic pancreatitis in seven dogs - ir:ir-batch6-83920001:14:25 2014-08-20
Serum alkaline phosphatase isoenzyme profiles in phenobarbital-treated epileptic dogs - ir:ir-batch6-39519321:24:10 2014-08-16
The Long Evans Cinnamon (LEC) rat develops hepatocellular damage in the absence of antimicrosomal antibodies - ir:ir-batch14-10439113:32:53 2014-08-20
Hepatotoxic effects associated to short and long term exposure to excess dietary copper in rats - ir:ir-batch14-10038710:25:34 2014-08-20