Effect of vehicular volume on the early pulmonary ...

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Title Effect of vehicular volume on the early pulmonary injury and inflammatory response in rats inoculated intratracheally with silica
Author(s) Alphonso Lopez, S. Yong, A. Sharma, M. Prior
Journal American Journal of Veterinary Research
Date 1987
Volume 48
Issue 8
Start page 1282
End page 1285
Abstract The effect of vehicular saline solution volume on early lesions induced in rats by intratracheal administration of silica was evaluated. Seventy-two male Long-Evans rats were randomly assigned 6 each to 12 factorial groups (3 .times. 2 .times. 2): 3 doses of silica (0, 2.5, and 5 mg), 2 volumes of vehicle (saline solution; 0.1 and 0.5 ml) and 2 postinoculation times (1 and 3 days). Lactate dehydrogenase and alkaline phosphatase activities in the bronchoalveolar lavage fluid supernatant and cell viability of bronchoalveolar cells were used as indicators of cell injury. The number of pulmonary alveolar macrophages and polymorphonuclear leukocytes were used as indicators of inflammatory response. Dose of silica and postinoculation time had a significant (P < 0.05) efect on the biochemical and cellular composition of lavage fluid. The volume of vehicle in which silica was suspended significantly (P < 0.05) enhanced the pulmonary injury and inflammatory response. However, dose-volume interaction was only significant (P < 0.05) in 1 of 6 parameters, indicating that the effect was additive, but not synergistic, in nature. Seemingly, vehicle volume had an enhanced effect on the injury and the inflammatory response induced by intratracheal inoculation of silica.

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