Development of an effective whole-spore vaccine to ...
|Title||Development of an effective whole-spore vaccine to protect against microsporidial gill disease in rainbow trout (Oncorhynchus mykiss) by using a low-virulence strain of Loma salmonae|
|Author(s)||D. J. Speare, R. J. F. Markham, N. J. Guselle|
|Journal||Clinical and Vaccine Immunology|
|Abstract||In determining the effective vaccine spore dose of a low-virulence strain of Loma salmonae to limit micro-sporidial gill disease in trout, we found that fish receiving 10(3) to 10(5) killed spores had the best protection against experimental infection, with 85% fewer xenomas in their gills than in the controls. Intraperitoneal delivery of the vaccine was effective, and the addition of adjuvant did not improve vaccine performance against this disease-causing microsporidian.|
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