Evidence that substance P may be a modulator rather ...

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Title Evidence that substance P may be a modulator rather than a transmitter of noxious mechanical stimulation
Author(s) Marva I. Sweeney-Nixon, J. Sawynok
Journal Canadian Journal of Physiology and Pharmacology
Date 1986
Volume 64
Issue 10
Start page 1324
End page 1327
Abstract Substance P (SP), injected intrathecally, produced a dose-related increase in responsiveness (hyperalgesia) in a pressure test for nociceptive thresholds. Pretreatment with two doses of SP produced complete desensitization to this response but did not alter base-line responsiveness. The hyperalgesic response to SP and the lack of change in base line following desensitization to SP suggest a modulator rather than a transmitter role for SP in the transmission of noxious mechanical stimulation.
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