Omega-3 polyunsaturated fatty acid regulation of ...

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Title Omega-3 polyunsaturated fatty acid regulation of gene expression
Author(s) P. T. Price, Carolanne M. Nelson, S. D. Clarke
Journal Current Opinion in Lipidology
Date 2000
Volume 11
Issue 1
Start page 3
Abstract This review describes the mechanisms by which polyunsaturated fatty acids regulate the activity of the nuclear transcription factors, peroxisome proliferator-activated receptor and sterol regulatory element binding protein-1, and it describes the role that the peroxisome proliferator-activated receptor and sterol regulatory element binding protein-1 play in coordinating the regulation of lipid synthesis, lipid oxidation, and thermogenesis. Finally, the requirement for dietary polyunsaturated fatty acids, particularly n-3 fatty acids, is defined in terms of the effects polyunsaturated fatty acids exert on gene expression and the role that these effects play in overall energy balance.

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