Anaphylactoid reactions to Mellavax [Salmonella ...
|Title||Anaphylactoid reactions to Mellavax [Salmonella dublin vaccine] in calves|
|Author(s)||John F. Burka, J. Scarnell|
|Abstract||Mellavax (avirulent S. dublin vaccine) appears to cause an anaphylactoid reaction in a ratio of 1:28 000 doses sold. A clinical picture of respiratory embarrassment and pulmonary oedema occurs. Histamine, 5-HT and dopamine are implicated mediators released during the reaction but to a minor extent compared with prostaglandins, which appear to play a major role in calves. Sodium meclofenamate, aspirin and indomethacin protect calves during acute systemic anaphylaxis and should be used in addition to adrenalin..|
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