Effects of modulators of arachidonic acid metabolism ...
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Citation
| Title | Effects of modulators of arachidonic acid metabolism on the synthesis and release of slow-reacting substance of anaphylaxis |
| Author(s) | J. Burka, R. Flower |
| Journal | British Journal of Pharmacology |
| Date | 1979 |
| Volume | 65 |
| Issue | 1 |
| Start page | 35 |
| End page | 41 |
| Abstract | 1 Slow-reacting substance of anaphylaxis (SRS-A) was released in the peritoneum of passively sensitized rats challenged with ovalbumin and from rat isolated peritoneal cells stimulated with calcium ionophore A23187. 2 Both monocytes (macrophages) and mast cells appear to be involved in the synthesis and release of SRS-A. 3 The immunological release of SRS-A in vivo is enhanced by indomethacin and inhibited by dexamethasone, mepacrine, 1-phenyl-3-pyrazolidone (1-P-3-P), and methylimidazole. 4 SRS-A release induced by A23187 in vitro is inhibited by dexamethasone, indomethacin 1-P-3-P, eicosatetraynoic acid (ETA) and 15-hydroperoxy arachidonic acid. The inhibition induced by dexamethasone, indomethacin and 1-P-3-P is reduced by an increase in the calcium concentration from 1 mM to 5 mM, whereas the inhibition induced by ETA is increased. 5 The results suggest that a lipoxygenase is important in the synthesis and release by SRS-A. |
Using APA 6th Edition citation style.
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