Modulation of the release of SRS-A from bovine lung ...



Title Modulation of the release of SRS-A from bovine lung in vitro by several autonomic and autacoid agents
Author(s) John F. Burka, P. Eyre
Journal International Archives of Allergy and Applied Immunology
Date 1976
Volume 50
Issue 6
Start page 664
End page 673
Abstract The immunological release of slow-reacting substance of anaphylaxis (SRS-A) from bovine lung is modulated by several autonomic and autacoid agents. Isoproterenol, a beta-adrenergic agonist, inhibited release of SRS-A, as did cyclic AMP. Phenylephrine also inhibited SRS-A release but through alpha-adrenergic mechanisms. This is in contrast to observations in human lung. Carbachol enhanced the release of bovine SRS-A. Histamine inhibited SRS-A release through the H2-receptor. Dopamine enhanced the release of SRS-A by means of a dopaminergic receptor. 5-HT did not significantly modulate SRS-A release.

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