Modulation of the formation and release of bovine ...



Title Modulation of the formation and release of bovine SRS-A in vitro by several anti-anaphylactic drugs
Author(s) John F. Burka, P. Eyre
Journal International Archives of Allergy and Applied Immunology
Date 1975
Volume 49
Issue 6
Start page 774
End page 781
Abstract Slow-reacting substance of anaphylaxis (SRS-A) is released immunologically from bovine lung in vitro. Various drugs known to protect calves and other animals during anaphylaxis were tested to investigate their modulation of the formation and release of SRS-A. The anti-inflammatory drugs, meclofenamate and aspirin, potentiated SRS-A release. Chlorphenesin and diethylcarbamazine citrate at high concentrations both inhibited SRS-A release. Two new anti-anaphylactic drugs, PR-D-92-EA and M&B 22,948, were particularly effective in inhibiting SRS-A release at low concentrations. The possible modes of actions of these drugs are discussed.

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